Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance

Kira D.A. Rienecker, Alexander T. Chavasse, Kim Moorwood, Andrew Ward, Anthony R. Isles

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10 +/p mice. Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. Isolation testing favors more territorial and aggressive behaviors, and does not address social dominance strategies employed in group housing contexts. Furthermore, isolation stress impacts midbrain function and dominance related behavior, often through alterations in monoaminergic signaling. Thus, we undertook a systematic study of Grb10 +/p social rank and dominance behavior within the cage group, using a number of convergent behavioral tests. We examined both male and female mice to account for sex differences and tested cohorts aged 2, 6 and 10 months to examine any developments related to age. We found group-housed Grb10 +/p mice do not show evidence of enhanced social dominance, but cages containing Grb10 +/p and wild-type mice lacked the normal correlation between three different measures of social rank. Moreover, a separate study indicated isolation stress induced inconsistent changes in tube test behavior. Taken together, these data suggest future research on Grb10 +/p mice should focus on the stability of social behaviors, rather than dominance per se.

Original languageEnglish
Article numbere12571
JournalGenes, Brain and Behavior
Early online date29 Apr 2019
DOIs
Publication statusE-pub ahead of print - 29 Apr 2019

Keywords

  • age
  • barbering
  • genomic imprinting
  • social dominance
  • social isolation

ASJC Scopus subject areas

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance. / Rienecker, Kira D.A.; Chavasse, Alexander T.; Moorwood, Kim; Ward, Andrew; Isles, Anthony R.

In: Genes, Brain and Behavior, 29.04.2019.

Research output: Contribution to journalArticle

@article{ed877c9f89244281b5e2fa8808297d23,
title = "Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance",
abstract = "Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10 +/p mice. Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. Isolation testing favors more territorial and aggressive behaviors, and does not address social dominance strategies employed in group housing contexts. Furthermore, isolation stress impacts midbrain function and dominance related behavior, often through alterations in monoaminergic signaling. Thus, we undertook a systematic study of Grb10 +/p social rank and dominance behavior within the cage group, using a number of convergent behavioral tests. We examined both male and female mice to account for sex differences and tested cohorts aged 2, 6 and 10 months to examine any developments related to age. We found group-housed Grb10 +/p mice do not show evidence of enhanced social dominance, but cages containing Grb10 +/p and wild-type mice lacked the normal correlation between three different measures of social rank. Moreover, a separate study indicated isolation stress induced inconsistent changes in tube test behavior. Taken together, these data suggest future research on Grb10 +/p mice should focus on the stability of social behaviors, rather than dominance per se.",
keywords = "age, barbering, genomic imprinting, social dominance, social isolation",
author = "Rienecker, {Kira D.A.} and Chavasse, {Alexander T.} and Kim Moorwood and Andrew Ward and Isles, {Anthony R.}",
note = "{\circledC} 2019 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.",
year = "2019",
month = "4",
day = "29",
doi = "10.1111/gbb.12571",
language = "English",
journal = "Genes, Brain and Behavior",
issn = "1601-1848",
publisher = "Wiley",

}

TY - JOUR

T1 - Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance

AU - Rienecker, Kira D.A.

AU - Chavasse, Alexander T.

AU - Moorwood, Kim

AU - Ward, Andrew

AU - Isles, Anthony R.

N1 - © 2019 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.

PY - 2019/4/29

Y1 - 2019/4/29

N2 - Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10 +/p mice. Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. Isolation testing favors more territorial and aggressive behaviors, and does not address social dominance strategies employed in group housing contexts. Furthermore, isolation stress impacts midbrain function and dominance related behavior, often through alterations in monoaminergic signaling. Thus, we undertook a systematic study of Grb10 +/p social rank and dominance behavior within the cage group, using a number of convergent behavioral tests. We examined both male and female mice to account for sex differences and tested cohorts aged 2, 6 and 10 months to examine any developments related to age. We found group-housed Grb10 +/p mice do not show evidence of enhanced social dominance, but cages containing Grb10 +/p and wild-type mice lacked the normal correlation between three different measures of social rank. Moreover, a separate study indicated isolation stress induced inconsistent changes in tube test behavior. Taken together, these data suggest future research on Grb10 +/p mice should focus on the stability of social behaviors, rather than dominance per se.

AB - Imprinted genes are highly expressed in monoaminergic regions of the midbrain and their functions in this area are thought to have an impact on mammalian social behaviors. One such imprinted gene is Grb10, of which the paternal allele is generally recognized as mediating social dominance behavior. However, there has been no detailed study of social dominance in Grb10 +/p mice. Moreover, the original study examined tube-test behavior in isolated mice 10 months of age. Isolation testing favors more territorial and aggressive behaviors, and does not address social dominance strategies employed in group housing contexts. Furthermore, isolation stress impacts midbrain function and dominance related behavior, often through alterations in monoaminergic signaling. Thus, we undertook a systematic study of Grb10 +/p social rank and dominance behavior within the cage group, using a number of convergent behavioral tests. We examined both male and female mice to account for sex differences and tested cohorts aged 2, 6 and 10 months to examine any developments related to age. We found group-housed Grb10 +/p mice do not show evidence of enhanced social dominance, but cages containing Grb10 +/p and wild-type mice lacked the normal correlation between three different measures of social rank. Moreover, a separate study indicated isolation stress induced inconsistent changes in tube test behavior. Taken together, these data suggest future research on Grb10 +/p mice should focus on the stability of social behaviors, rather than dominance per se.

KW - age

KW - barbering

KW - genomic imprinting

KW - social dominance

KW - social isolation

UR - http://www.scopus.com/inward/record.url?scp=85065189296&partnerID=8YFLogxK

U2 - 10.1111/gbb.12571

DO - 10.1111/gbb.12571

M3 - Article

JO - Genes, Brain and Behavior

JF - Genes, Brain and Behavior

SN - 1601-1848

M1 - e12571

ER -