Designing Zn(II) and Cu(II) derivatives as probes for in vitro fluorescence imaging

Sofia I Pascu, P A Waghorn, T D Conry, H M Betts, J R Dilworth, G C Churchill, T Pokrovska, M Christlieb, F I Aigbirhio, J E Warren

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

New M( II) bis(thiosemicarbazonato) complexes ( M = Ni( II), Cu( II) and Zn( II)) featuring allyl groups at the exocyclic nitrogens have been synthesised. The complexes were characterised in solution by spectroscopic methods and their solid state structures determined by single crystal X-ray diffraction using synchrotron radiation. The Zn( II) complex was found to be intrinsically fluorescent and soluble in biocompatible media. The uptake of this Zn( II) complex in HeLa, MCF-7 and IGROV cancer cells was monitored by fluorescence microscopies ( epi- and confocal fluorescence imaging). The radiolabelling to Cu-64( II) bis( thiosemicarbazonato) complex was performed cleanly by transmetallation from the corresponding Zn( II) species using Cu-64( OAc)(2).
Original languageEnglish
Pages (from-to)4988-4997
Number of pages10
JournalDalton Transactions
Volume2007
Issue number43
DOIs
Publication statusPublished - 2007

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