Abstract
The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.
| Original language | English |
|---|---|
| Pages (from-to) | 1452-1456 |
| Number of pages | 5 |
| Journal | MedChemComm |
| Volume | 4 |
| Issue number | 11 |
| Early online date | 17 Sept 2013 |
| DOIs | |
| Publication status | Published - Nov 2013 |
Bibliographical note
Copyright:Copyright 2013 Elsevier B.V., All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
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