Design, synthesis and antiproliferative activity of indole analogues of indanocine

Gemma A. Tunbridge; Joseph Oram; Lorenzo Caggiano

doi:10.1039/C3MD00200D

Design, synthesis and antiproliferative activity of indole analogues of indanocine

Gemma A. Tunbridge, Joseph Oram, Lorenzo Caggiano

Department of Life Sciences

University of Bath

Research output: Contribution to journal › Article › peer-review

30 Citations (SciVal)

184 Downloads (Pure)

Abstract

The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI₅₀ < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.

Original language	English
Pages (from-to)	1452-1456
Number of pages	5
Journal	MedChemComm
Volume	4
Issue number	11
Early online date	17 Sept 2013
DOIs	https://doi.org/10.1039/C3MD00200D https://doi.org/10.1039/c3md00200d
Publication status	Published - Nov 2013

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/C3MD00200D
10.1039/c3md00200dLicence: CC BY

published paper
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Final published version, 195 KBLicence: CC BY

Cite this

@article{c1bddc762271418f8b42cc8b582d9187,

title = "Design, synthesis and antiproliferative activity of indole analogues of indanocine",

abstract = "The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.",

author = "Tunbridge, {Gemma A.} and Joseph Oram and Lorenzo Caggiano",

year = "2013",

month = nov,

doi = "10.1039/C3MD00200D",

language = "English",

volume = "4",

pages = "1452--1456",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "11",

}

TY - JOUR

T1 - Design, synthesis and antiproliferative activity of indole analogues of indanocine

AU - Tunbridge, Gemma A.

AU - Oram, Joseph

AU - Caggiano, Lorenzo

PY - 2013/11

Y1 - 2013/11

N2 - The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.

AB - The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.

UR - http://www.scopus.com/inward/record.url?scp=84878798574&partnerID=8YFLogxK

UR - http://pubs.rsc.org/en/content/articlepdf/2013/md/c3md00200d

UR - http://www.rsc.org/suppdata/md/c3/c3md00200d/c3md00200d.pdf

UR - http://people.bath.ac.uk/lc287/publications.html

UR - http://dx.doi.org/10.1039/C3MD00200D

U2 - 10.1039/C3MD00200D

DO - 10.1039/C3MD00200D

M3 - Article

AN - SCOPUS:84878798574

SN - 2040-2503

VL - 4

SP - 1452

EP - 1456

JO - MedChemComm

JF - MedChemComm

IS - 11

ER -

Design, synthesis and antiproliferative activity of indole analogues of indanocine

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this