TY - JOUR
T1 - Design, synthesis and antiproliferative activity of indole analogues of indanocine.
AU - Tunbridge, Gemma A
AU - Oram, Joseph
AU - Caggiano, L
PY - 2013
Y1 - 2013
N2 - The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.
AB - The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.
UR - http://www.scopus.com/inward/record.url?scp=84878798574&partnerID=8YFLogxK
UR - http://pubs.rsc.org/en/content/articlepdf/2013/md/c3md00200d
UR - http://www.rsc.org/suppdata/md/c3/c3md00200d/c3md00200d.pdf
UR - http://people.bath.ac.uk/lc287/publications.html
UR - http://dx.doi.org/10.1039/C3MD00200D
U2 - 10.1039/C3MD00200D
DO - 10.1039/C3MD00200D
M3 - Article
AN - SCOPUS:84878798574
VL - 4
SP - 1452
EP - 1456
JO - MedChemComm
JF - MedChemComm
SN - 2040-2503
IS - 11
ER -