Design, synthesis and antiproliferative activity of indole analogues of indanocine

Gemma A. Tunbridge, Joseph Oram, Lorenzo Caggiano

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)
115 Downloads (Pure)

Abstract

The design and synthesis of a novel series of indole-analogues of indanocine is reported, together with their antiproliferative activity in the NCI's panel of cancer cell lines. Indanocine displays potent activity against a wide range of cancer cell lines (mean GI50 < 20 nM), including drug-resistant cancer cell lines, and also inhibits the migration of metastatic cancer cells. A number of the described indole-analogues display a similar activity profile to indanocine, exhibiting potent antiproliferative activities in several cancer cell lines, and offer new leads for further development.

Original languageEnglish
Pages (from-to)1452-1456
Number of pages5
JournalMedChemComm
Volume4
Issue number11
Early online date17 Sep 2013
DOIs
Publication statusPublished - Nov 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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