Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Takayoshi Tsuzuki; Natsumi Sakaguchi; Takashi Kudoh; Satoshi Takano; Masato Uehara; Takashi Murayama; Takashi Sakurai; Minako Hashii; Haruhiro Higashida; K. Weber; Andreas H. Guse; Tomoshi Kameda; Takatsugu  Hirokawa; Yasuhiro Kumaki; Barry V. L. Potter; Hayato Fukuda; Mitsuhiro Arisawa; Satoshi Shuto

doi:10.1002/anie.201302098

Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Takayoshi Tsuzuki, Natsumi Sakaguchi, Takashi Kudoh, Satoshi Takano, Masato Uehara, Takashi Murayama, Takashi Sakurai, Minako Hashii, Haruhiro Higashida, K. Weber, Andreas H. Guse, Tomoshi Kameda, Takatsugu Hirokawa, Yasuhiro Kumaki, Barry V. L. Potter, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

Abstract

Oh, what a difference an S makes: A thioribose analogue (cADPtR, see scheme) of cyclic ADP-ribose (cADPR) was synthesized that is stable and has structural and electrostatic features similar to those of cADPR. cADPtR is the first stable equivalent of cADPR that is as active as cADPR in various cellular systems, making it useful for investigating Ca ion-release signaling pathways.

Original language	English
Pages (from-to)	6633-6637
Journal	Angewandte Chemie International Edition
Volume	52
Issue number	26
DOIs	https://doi.org/10.1002/anie.201302098
Publication status	Published - 24 Jun 2013

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Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M., & Shuto, S. (2013). Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. Angewandte Chemie International Edition, 52(26), 6633-6637. https://doi.org/10.1002/anie.201302098

Tsuzuki, T, Sakaguchi, N, Kudoh, T, Takano, S, Uehara, M, Murayama, T, Sakurai, T, Hashii, M, Higashida, H, Weber, K, Guse, AH, Kameda, T, Hirokawa, T, Kumaki, Y, Potter, BVL, Fukuda, H, Arisawa, M & Shuto, S 2013, 'Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger', Angewandte Chemie International Edition, vol. 52, no. 26, pp. 6633-6637. https://doi.org/10.1002/anie.201302098

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AU - Kudoh, Takashi

AU - Takano, Satoshi

AU - Uehara, Masato

AU - Murayama, Takashi

AU - Sakurai, Takashi

AU - Hashii, Minako

AU - Higashida, Haruhiro

AU - Weber, K.

AU - Guse, Andreas H.

AU - Kameda, Tomoshi

AU - Hirokawa, Takatsugu

AU - Kumaki, Yasuhiro

AU - Potter, Barry V. L.

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AU - Arisawa, Mitsuhiro

AU - Shuto, Satoshi

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Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

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