Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger

Takayoshi Tsuzuki, Natsumi Sakaguchi, Takashi Kudoh, Satoshi Takano, Masato Uehara, Takashi Murayama, Takashi Sakurai, Minako Hashii, Haruhiro Higashida, K. Weber, Andreas H. Guse, Tomoshi Kameda, Takatsugu Hirokawa, Yasuhiro Kumaki, Barry V. L. Potter, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto

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13 Citations (Scopus)

Abstract

Oh, what a difference an S makes: A thioribose analogue (cADPtR, see scheme) of cyclic ADP-ribose (cADPR) was synthesized that is stable and has structural and electrostatic features similar to those of cADPR. cADPtR is the first stable equivalent of cADPR that is as active as cADPR in various cellular systems, making it useful for investigating Ca ion-release signaling pathways.
Original languageEnglish
Pages (from-to)6633-6637
JournalAngewandte Chemie-International Edition
Volume52
Issue number26
DOIs
Publication statusPublished - 24 Jun 2013

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    Tsuzuki, T., Sakaguchi, N., Kudoh, T., Takano, S., Uehara, M., Murayama, T., Sakurai, T., Hashii, M., Higashida, H., Weber, K., Guse, A. H., Kameda, T., Hirokawa, T., Kumaki, Y., Potter, B. V. L., Fukuda, H., Arisawa, M., & Shuto, S. (2013). Design and synthesis of cyclic ADP-4-thioribose as a stable equivalent of cyclic ADP-ribose, a calcium ion-mobilizing second messenger. Angewandte Chemie-International Edition, 52(26), 6633-6637. https://doi.org/10.1002/anie.201302098