Design and synthesis of artificial ion channels

Gordon G Cross, Thomas M Fyles, Tony D James, Mohammad Zojaji

Research output: Contribution to journalArticlepeer-review


The synthesis of a series of functional artifical ion channels is described. Candidate structures are assembled from a modular construction set of subunits consisting of a core crown ether unit for structural organization, multiple macrocyclic tetraester wall units to span a bilayer membrane, and polar head units to impart amphiphilic character. The modular assembly approach allowed the efficient synthesis of a suite of compounds but the inherent properties of the construction set limited the range of synthetically accessible structures.
Original languageEnglish
Pages (from-to)449-460
Number of pages12
Issue number07
Publication statusPublished - 1993


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