Abstract
The synthesis of a series of functional artifical ion channels is described. Candidate structures are assembled from a modular construction set of subunits consisting of a core crown ether unit for structural organization, multiple macrocyclic tetraester wall units to span a bilayer membrane, and polar head units to impart amphiphilic character. The modular assembly approach allowed the efficient synthesis of a suite of compounds but the inherent properties of the construction set limited the range of synthetically accessible structures.
Original language | English |
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Pages (from-to) | 449-460 |
Number of pages | 12 |
Journal | Synlett |
Volume | 1993 |
Issue number | 07 |
DOIs | |
Publication status | Published - 1993 |