TY - JOUR
T1 - Design and In Vitro Interference Test of Microwave Noninvasive Blood Glucose Monitoring Sensor
AU - Choi, Heungjae
AU - Naylon, Jack
AU - Luzio, Steve
AU - Beutler, Jan
AU - Birchall, James
AU - Martin, Chris
AU - Porch, Adrian
AU - Martin, Christopher
PY - 2015/9/3
Y1 - 2015/9/3
N2 - A design of a microwave noninvasive continuous blood glucose monitoring sensor and its interference test results are presented. The novelty of the proposed sensor is that it comprises two spatially separated split-ring resonators, where one interacts with the change in glucose level of a sample under test while the other ring is used as a reference. The reference ring has a slightly different resonant frequency and is desensitized to the sample owing to its location, thus allowing changes in temperature to be calibrated out. From an oral glucose tolerance test with two additional commercially available sensors (blood strip and continuous glucose monitor) in parallel, we obtained encouraging performance for our sensor comparable with those of the commercial sensors. The effects of endogenous interferents common to all subjects, i.e., common sugars, vitamins (ascorbic acid), and metabolites (uric acid) have also been investigated by using a large Franz cell assembly. From the interference test, it is shown that the change in sensor response is dominated by changes in glucose level for concentrations relevant to blood, and the effects of interferents are negligible in comparison.
AB - A design of a microwave noninvasive continuous blood glucose monitoring sensor and its interference test results are presented. The novelty of the proposed sensor is that it comprises two spatially separated split-ring resonators, where one interacts with the change in glucose level of a sample under test while the other ring is used as a reference. The reference ring has a slightly different resonant frequency and is desensitized to the sample owing to its location, thus allowing changes in temperature to be calibrated out. From an oral glucose tolerance test with two additional commercially available sensors (blood strip and continuous glucose monitor) in parallel, we obtained encouraging performance for our sensor comparable with those of the commercial sensors. The effects of endogenous interferents common to all subjects, i.e., common sugars, vitamins (ascorbic acid), and metabolites (uric acid) have also been investigated by using a large Franz cell assembly. From the interference test, it is shown that the change in sensor response is dominated by changes in glucose level for concentrations relevant to blood, and the effects of interferents are negligible in comparison.
UR - http://www.scopus.com/inward/record.url?scp=84941047000&partnerID=8YFLogxK
UR - http://doi.org/10.1109/TMTT.2015.2472019
U2 - 10.1109/TMTT.2015.2472019
DO - 10.1109/TMTT.2015.2472019
M3 - Article
SN - 0018-9480
VL - 63
SP - 3016
EP - 3025
JO - IEEE Transactions on Microwave Theory and Techniques
JF - IEEE Transactions on Microwave Theory and Techniques
IS - 10
ER -