Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose

N. García-González, I. W. Kellaway, H. Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F. J. Otero-Espinar, J. Blanco-Méndez

Research output: Contribution to journalArticle

Abstract

We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased sucrose concentration led to reduced swelling and reduced drug release efficiency.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalInternational Journal of Pharmaceutics
Volume100
Issue number1-3
DOIs
Publication statusPublished - 8 Nov 1993

Keywords

  • Carbopol
  • Crosslinking
  • Dissolution
  • Hydrogel
  • Metoclopramide
  • Sucrose
  • Swelling

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    García-González, N., Kellaway, I. W., Blanco-Fuente, H., Anguiano-Igea, S., Delgado-Charro, B., Otero-Espinar, F. J., & Blanco-Méndez, J. (1993). Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose. International Journal of Pharmaceutics, 100(1-3), 65-70. https://doi.org/10.1016/0378-5173(93)90076-R