Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose

N. García-González; I. W. Kellaway; H. Blanco-Fuente; S. Anguiano-Igea; B. Delgado-Charro; F. J. Otero-Espinar; J. Blanco-Méndez

doi:10.1016/0378-5173(93)90076-R

Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose

N. García-González, I. W. Kellaway, H. Blanco-Fuente, S. Anguiano-Igea, B. Delgado-Charro, F. J. Otero-Espinar, J. Blanco-Méndez

Department of Life Sciences

Universidade de Santiago de Compostela

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased sucrose concentration led to reduced swelling and reduced drug release efficiency.

Original language	English
Pages (from-to)	65-70
Number of pages	6
Journal	International Journal of Pharmaceutics
Volume	100
Issue number	1-3
DOIs	https://doi.org/10.1016/0378-5173(93)90076-R
Publication status	Published - 8 Nov 1993

Keywords

Carbopol
Crosslinking
Dissolution
Hydrogel
Metoclopramide
Sucrose
Swelling

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10.1016/0378-5173(93)90076-R

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García-González, N., Kellaway, I. W., Blanco-Fuente, H., Anguiano-Igea, S., Delgado-Charro, B., Otero-Espinar, F. J., & Blanco-Méndez, J. (1993). Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose. International Journal of Pharmaceutics, 100(1-3), 65-70. https://doi.org/10.1016/0378-5173(93)90076-R

García-González, N, Kellaway, IW, Blanco-Fuente, H, Anguiano-Igea, S, Delgado-Charro, B, Otero-Espinar, FJ & Blanco-Méndez, J 1993, 'Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose', International Journal of Pharmaceutics, vol. 100, no. 1-3, pp. 65-70. https://doi.org/10.1016/0378-5173(93)90076-R

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abstract = "We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased sucrose concentration led to reduced swelling and reduced drug release efficiency.",

keywords = "Carbopol, Crosslinking, Dissolution, Hydrogel, Metoclopramide, Sucrose, Swelling",

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doi = "10.1016/0378-5173(93)90076-R",

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T1 - Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose

AU - García-González, N.

AU - Kellaway, I. W.

AU - Blanco-Fuente, H.

AU - Anguiano-Igea, S.

AU - Delgado-Charro, B.

AU - Otero-Espinar, F. J.

AU - Blanco-Méndez, J.

PY - 1993/11/8

Y1 - 1993/11/8

N2 - We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased sucrose concentration led to reduced swelling and reduced drug release efficiency.

AB - We evaluated the effects of polyacrylic acid (PAA) molecular weight and crosslinking agent (sucrose) concentration on swelling and drug (metoclopramide) release characteristics of PAA (Carbopol) hydrogels. Both factors, and the interactions between them, were found to have significant effects on both hydrogel swelling and drug release. In particular, increased sucrose concentration led to reduced swelling and reduced drug release efficiency.

KW - Carbopol

KW - Crosslinking

KW - Dissolution

KW - Hydrogel

KW - Metoclopramide

KW - Sucrose

KW - Swelling

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M3 - Article

AN - SCOPUS:0027366795

SN - 0378-5173

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JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-3

ER -

Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose

Abstract

Keywords

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