Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

Karen Robertson; Pierre-Baptiste Flandrin; Anneke R. Klapwijk; Chick C. Wilson

doi:10.1021/acs.cgd.6b00885

Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

Karen Robertson, Pierre-Baptiste Flandrin, Anneke R. Klapwijk, Chick C. Wilson

Research output: Contribution to journal › Article › peer-review

20 Citations (SciVal)

104 Downloads (Pure)

Abstract

The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixing throughout the reactor length while helping prevent encrustation issues experienced by other precipitation reactors and crystallizers. Evaluation of the reactor for production of solid-state particle products has been carried out using cooling crystallization of fast growing succinic acid to explore the potential of the KRAIC design to mediate blocking caused during the precipitation process. The segmented flow environment is successful in preventing encrustation during an unseeded 2 h cooling crystallization experiment.

Original language	English
Pages (from-to)	4759-4764
Journal	Crystal Growth and Design
Volume	16
Issue number	8
Early online date	11 Jul 2016
DOIs	https://doi.org/10.1021/acs.cgd.6b00885
Publication status	Published - 3 Aug 2016

Access to Document

10.1021/acs.cgd.6b00885

Design and Evaluation of a Meso-scale Segmented Flow Reactor - KRobertson et al
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.cgd.6b00885
Accepted author manuscript, 8.77 MB

http://pubs.acs.org/doi/abs/10.1021/acs.cgd.6b00885

Cite this

@article{8c641e6a3ed74499b2b4fb5af3effaec,

title = "Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)",

abstract = "The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixing throughout the reactor length while helping prevent encrustation issues experienced by other precipitation reactors and crystallizers. Evaluation of the reactor for production of solid-state particle products has been carried out using cooling crystallization of fast growing succinic acid to explore the potential of the KRAIC design to mediate blocking caused during the precipitation process. The segmented flow environment is successful in preventing encrustation during an unseeded 2 h cooling crystallization experiment.",

author = "Karen Robertson and Pierre-Baptiste Flandrin and Klapwijk, {Anneke R.} and Wilson, {Chick C.}",

year = "2016",

month = aug,

day = "3",

doi = "10.1021/acs.cgd.6b00885",

language = "English",

volume = "16",

pages = "4759--4764",

journal = "Crystal Growth and Design",

issn = "1528-7483",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

AU - Robertson, Karen

AU - Flandrin, Pierre-Baptiste

AU - Klapwijk, Anneke R.

AU - Wilson, Chick C.

PY - 2016/8/3

Y1 - 2016/8/3

N2 - The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixing throughout the reactor length while helping prevent encrustation issues experienced by other precipitation reactors and crystallizers. Evaluation of the reactor for production of solid-state particle products has been carried out using cooling crystallization of fast growing succinic acid to explore the potential of the KRAIC design to mediate blocking caused during the precipitation process. The segmented flow environment is successful in preventing encrustation during an unseeded 2 h cooling crystallization experiment.

AB - The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixing throughout the reactor length while helping prevent encrustation issues experienced by other precipitation reactors and crystallizers. Evaluation of the reactor for production of solid-state particle products has been carried out using cooling crystallization of fast growing succinic acid to explore the potential of the KRAIC design to mediate blocking caused during the precipitation process. The segmented flow environment is successful in preventing encrustation during an unseeded 2 h cooling crystallization experiment.

UR - http://dx.doi.org/10.1021/acs.cgd.6b00885

U2 - 10.1021/acs.cgd.6b00885

DO - 10.1021/acs.cgd.6b00885

M3 - Article

VL - 16

SP - 4759

EP - 4764

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 8

ER -

Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

Abstract

Access to Document

Other files and links

Fingerprint

Applying Long-Lived Metastable States in Switchable Functionality via Kinetic Control of Molecular Assembly

Cite this

Design and Evaluation of a Mesoscale Segmented Flow Reactor (KRAIC)

Abstract

Access to Document

Other files and links

Fingerprint

Projects

Applying Long-Lived Metastable States in Switchable Functionality via Kinetic Control of Molecular Assembly

Cite this