Design and development of a nozzle-free electrospinning device for the high-throughput production of biomaterial nanofibers

Muhammad Waqas, Antonios Keirouz, Maria Kana Sanira Putri, Faraz Fazal, Francisco Javier Diaz Sanchez, Dipa Ray, Vasileios Koutsos, Norbert Radacsi

Research output: Contribution to journalArticlepeer-review

13 Citations (SciVal)
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This technical note provides a step-by-step guide for the design and construction of a temperature-controlled nozzle-free electrospinning device. The equipment uses a rotating mandrel partially immersed within a polymer solution to produce fibers in an upward motion by inducing the formation of multiple Taylor cones and subsequently multi-jetting out of an electrified open surface. Free-surface electrospinning can overcome limitations and drawbacks associated with single and multi-nozzle spinneret configurations, such as low yield, limited production capacity, nonuniform electric field distribution, and clogging. Most importantly, this lab-scaled high-throughput device can provide an alternative economical route for needleless electrospinning research, in contrast to the high costs associated with industrially available upscaling equipment. Among the device's technical specifications, a key feature is a cryo-collector mandrel, capable of collecting fibers in sub-zero temperatures, which can induce ultra-porous nanostructures, wider pores, and subsequent in-depth penetration of cells. A multi-channel gas chamber allows the conditioning of the atmosphere, temperature, and airflow, while the chamber's design averts user exposure to the high-voltage components. All the Computer-Aided Design (CAD) files and point-by-point assembly instructions, along with a list of the materials used, are provided.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalMedical Engineering and Physics
Early online date6 May 2021
Publication statusPublished - 30 Jun 2021


  • biomaterials
  • cryo-electrospinning
  • electrospinning
  • high-throughput
  • nanofibers
  • Nozzle-free

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering


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