Abstract

Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical re-entry scenarios involve potential skin exposure to a "dried residue" of the spray dilution, from which the absorption of a pesticide may be quite different. The research reported in this paper has shown: (1) The method to assess the transfer of dried pesticide residues from a surface to the skin is reproducible for four active ingredients of diverse physicochemical properties, after their application in commercially relevant formulations. (2) Skin absorption of all four pesticides examined was significantly less from a dried residue than from a spray dilution; the difference, in general, was of the order of a factor of 2. (3) Decontamination experiments with one of the active ingredients tested (trinexapac-ethyl) showed that, post-exposure to a spray dilution, skin surface cleaning must be performed within 1 h to significantly reduce potential systemic exposure (relative to continual contact for 24 h); in contrast, after contact with a dried residue, the sooner decontamination was performed, the greater the decrease in exposure achieved, even when the time of contact was as long as 8 h.

Original languageEnglish
Pages (from-to)1356-1363
JournalChemical Research in Toxicology
Volume31
Issue number12
Early online date23 Nov 2018
DOIs
Publication statusPublished - 17 Dec 2018

Keywords

  • dermal absorption
  • pesticide
  • risk assessment
  • re-entry
  • residue

Cite this

Dermal Absorption of Pesticide Residues. / Clarke, James; Cordery, Sarah; Morgan, Neil A.; Knowles, Peter ; Guy, Richard.

In: Chemical Research in Toxicology, Vol. 31, No. 12, 17.12.2018, p. 1356-1363.

Research output: Contribution to journalArticle

Clarke, J, Cordery, S, Morgan, NA, Knowles, P & Guy, R 2018, 'Dermal Absorption of Pesticide Residues', Chemical Research in Toxicology, vol. 31, no. 12, pp. 1356-1363. https://doi.org/10.1021/acs.chemrestox.8b00227
Clarke, James ; Cordery, Sarah ; Morgan, Neil A. ; Knowles, Peter ; Guy, Richard. / Dermal Absorption of Pesticide Residues. In: Chemical Research in Toxicology. 2018 ; Vol. 31, No. 12. pp. 1356-1363.
@article{32b3f0f5a2344d25be74cdb04038d080,
title = "Dermal Absorption of Pesticide Residues",
abstract = "Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical re-entry scenarios involve potential skin exposure to a {"}dried residue{"} of the spray dilution, from which the absorption of a pesticide may be quite different. The research reported in this paper has shown: (1) The method to assess the transfer of dried pesticide residues from a surface to the skin is reproducible for four active ingredients of diverse physicochemical properties, after their application in commercially relevant formulations. (2) Skin absorption of all four pesticides examined was significantly less from a dried residue than from a spray dilution; the difference, in general, was of the order of a factor of 2. (3) Decontamination experiments with one of the active ingredients tested (trinexapac-ethyl) showed that, post-exposure to a spray dilution, skin surface cleaning must be performed within 1 h to significantly reduce potential systemic exposure (relative to continual contact for 24 h); in contrast, after contact with a dried residue, the sooner decontamination was performed, the greater the decrease in exposure achieved, even when the time of contact was as long as 8 h.",
keywords = "dermal absorption, pesticide, risk assessment, re-entry, residue",
author = "James Clarke and Sarah Cordery and Morgan, {Neil A.} and Peter Knowles and Richard Guy",
year = "2018",
month = "12",
day = "17",
doi = "10.1021/acs.chemrestox.8b00227",
language = "English",
volume = "31",
pages = "1356--1363",
journal = "Chemical Research in Toxicology",
issn = "0893-228X",
publisher = "American Chemical Society",
number = "12",

}

TY - JOUR

T1 - Dermal Absorption of Pesticide Residues

AU - Clarke, James

AU - Cordery, Sarah

AU - Morgan, Neil A.

AU - Knowles, Peter

AU - Guy, Richard

PY - 2018/12/17

Y1 - 2018/12/17

N2 - Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical re-entry scenarios involve potential skin exposure to a "dried residue" of the spray dilution, from which the absorption of a pesticide may be quite different. The research reported in this paper has shown: (1) The method to assess the transfer of dried pesticide residues from a surface to the skin is reproducible for four active ingredients of diverse physicochemical properties, after their application in commercially relevant formulations. (2) Skin absorption of all four pesticides examined was significantly less from a dried residue than from a spray dilution; the difference, in general, was of the order of a factor of 2. (3) Decontamination experiments with one of the active ingredients tested (trinexapac-ethyl) showed that, post-exposure to a spray dilution, skin surface cleaning must be performed within 1 h to significantly reduce potential systemic exposure (relative to continual contact for 24 h); in contrast, after contact with a dried residue, the sooner decontamination was performed, the greater the decrease in exposure achieved, even when the time of contact was as long as 8 h.

AB - Current guidance for dermal exposure assessment of plant protection products typically uses in vitro skin penetration data for the active ingredient when applied as both the concentrated product and relevant spray dilutions thereof. However, typical re-entry scenarios involve potential skin exposure to a "dried residue" of the spray dilution, from which the absorption of a pesticide may be quite different. The research reported in this paper has shown: (1) The method to assess the transfer of dried pesticide residues from a surface to the skin is reproducible for four active ingredients of diverse physicochemical properties, after their application in commercially relevant formulations. (2) Skin absorption of all four pesticides examined was significantly less from a dried residue than from a spray dilution; the difference, in general, was of the order of a factor of 2. (3) Decontamination experiments with one of the active ingredients tested (trinexapac-ethyl) showed that, post-exposure to a spray dilution, skin surface cleaning must be performed within 1 h to significantly reduce potential systemic exposure (relative to continual contact for 24 h); in contrast, after contact with a dried residue, the sooner decontamination was performed, the greater the decrease in exposure achieved, even when the time of contact was as long as 8 h.

KW - dermal absorption

KW - pesticide

KW - risk assessment

KW - re-entry

KW - residue

UR - http://www.scopus.com/inward/record.url?scp=85058527797&partnerID=8YFLogxK

U2 - 10.1021/acs.chemrestox.8b00227

DO - 10.1021/acs.chemrestox.8b00227

M3 - Article

VL - 31

SP - 1356

EP - 1363

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

SN - 0893-228X

IS - 12

ER -