Deep tissue contractility sensing with biointegrated microlasers

Marcel Schubert; Lewis Woolfson; Isla R.M. Barnard; Amy M. Dorward; Becky Casement; Soraya Caixeiro; Andrew Morton; Gavin B. Robertson; Paul L. Appleton; Gareth B. Miles; Carl S. Tucker; Samantha J. Pitt; Malte C. Gather

doi:10.1364/NTM.2021.NW3C.2

Deep tissue contractility sensing with biointegrated microlasers

Marcel Schubert, Lewis Woolfson, Isla R.M. Barnard, Amy M. Dorward, Becky Casement, Soraya Caixeiro, Andrew Morton, Gavin B. Robertson, Paul L. Appleton, Gareth B. Miles, Carl S. Tucker, Samantha J. Pitt, Malte C. Gather

Department of Physics

Research output: Chapter or section in a book/report/conference proceeding › Book chapter

Abstract

Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.

Original language	English
Title of host publication	OSA Technical Digest
DOIs	https://doi.org/10.1364/NTM.2021.NW3C.2
Publication status	Published - 16 Apr 2021
Event	Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 - Virtual, Online, USA United States Duration: 12 Apr 2021 → 16 Apr 2021

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Print)	2162-2701

Conference

Conference	Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021
Country/Territory	USA United States
City	Virtual, Online
Period	12/04/21 → 16/04/21

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

Access to Document

10.1364/NTM.2021.NW3C.2

Cite this

Schubert, M., Woolfson, L., Barnard, I. R. M., Dorward, A. M., Casement, B., Caixeiro, S., Morton, A., Robertson, G. B., Appleton, P. L., Miles, G. B., Tucker, C. S., Pitt, S. J., & Gather, M. C. (2021). Deep tissue contractility sensing with biointegrated microlasers. In OSA Technical Digest (Optics InfoBase Conference Papers). https://doi.org/10.1364/NTM.2021.NW3C.2

Schubert, M, Woolfson, L, Barnard, IRM, Dorward, AM, Casement, B, Caixeiro, S, Morton, A, Robertson, GB, Appleton, PL, Miles, GB, Tucker, CS, Pitt, SJ & Gather, MC 2021, Deep tissue contractility sensing with biointegrated microlasers. in OSA Technical Digest . Optics InfoBase Conference Papers, Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021, Virtual, Online, USA United States, 12/04/21. https://doi.org/10.1364/NTM.2021.NW3C.2

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title = "Deep tissue contractility sensing with biointegrated microlasers",

abstract = "Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.",

author = "Marcel Schubert and Lewis Woolfson and Barnard, \{Isla R.M.\} and Dorward, \{Amy M.\} and Becky Casement and Soraya Caixeiro and Andrew Morton and Robertson, \{Gavin B.\} and Appleton, \{Paul L.\} and Miles, \{Gareth B.\} and Tucker, \{Carl S.\} and Pitt, \{Samantha J.\} and Gather, \{Malte C.\}",

year = "2021",

month = apr,

day = "16",

doi = "10.1364/NTM.2021.NW3C.2",

language = "English",

series = "Optics InfoBase Conference Papers",

booktitle = "OSA Technical Digest",

note = "Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 ; Conference date: 12-04-2021 Through 16-04-2021",

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TY - CHAP

T1 - Deep tissue contractility sensing with biointegrated microlasers

AU - Schubert, Marcel

AU - Woolfson, Lewis

AU - Barnard, Isla R.M.

AU - Dorward, Amy M.

AU - Casement, Becky

AU - Caixeiro, Soraya

AU - Morton, Andrew

AU - Robertson, Gavin B.

AU - Appleton, Paul L.

AU - Miles, Gareth B.

AU - Tucker, Carl S.

AU - Pitt, Samantha J.

AU - Gather, Malte C.

PY - 2021/4/16

Y1 - 2021/4/16

N2 - Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.

AB - Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.

UR - https://www.scopus.com/pages/publications/85119685615

U2 - 10.1364/NTM.2021.NW3C.2

DO - 10.1364/NTM.2021.NW3C.2

M3 - Book chapter

AN - SCOPUS:85119685615

T3 - Optics InfoBase Conference Papers

BT - OSA Technical Digest

T2 - Novel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021

Y2 - 12 April 2021 through 16 April 2021

ER -

Deep tissue contractility sensing with biointegrated microlasers

Abstract

Publication series

Conference

ASJC Scopus subject areas

Access to Document

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