Decision-making ability, psychopathology, and brain connectivity

NSPN Consortium

doi:10.1016/j.neuron.2021.04.019

Decision-making ability, psychopathology, and brain connectivity

NSPN Consortium

Research output: Contribution to journal › Article › peer-review

28 Citations (SciVal)

Abstract

Decision-making is a cognitive process of central importance for the quality of our lives. Here, we ask whether a common factor underpins our diverse decision-making abilities. We obtained 32 decision-making measures from 830 young people and identified a common factor that we call “decision acuity,” which was distinct from IQ and reflected a generic decision-making ability. Decision acuity was decreased in those with aberrant thinking and low general social functioning. Crucially, decision acuity and IQ had dissociable brain signatures, in terms of their associated neural networks of resting-state functional connectivity. Decision acuity was reliably measured, and its relationship with functional connectivity was also stable when measured in the same individuals 18 months later. Thus, our behavioral and brain data identify a new cognitive construct that underpins decision-making ability across multiple domains. This construct may be important for understanding mental health, particularly regarding poor social function and aberrant thought patterns.

Original language	English
Pages (from-to)	2025-2040.e7
Journal	Neuron
Volume	109
Issue number	12
Early online date	20 May 2021
DOIs	https://doi.org/10.1016/j.neuron.2021.04.019
Publication status	Published - 16 Jun 2021

Funding

The Wellcome Trust funded the “Neuroscience in Psychiatry Project” (NSPN). All NSPN members (supplemental information, section E) were supported by the Wellcome Strategic Award, ref. 095844/7/11/Z. R.J.D. is supported by a Wellcome Investigator Award, ref. 098362/Z/12/Z. Statistical analyses were also enabled by resources provided by the Swedish National Infrastructure for Computing (SNIC) at the HPC2N center, partially funded by the Swedish Research Council through grant agreement no. 2016-07213. The Max Planck – UCL Centre for Computational Psychiatry and Aging is a joint initiative of the Max Planck Society and UCL. D.R.B. is supported by funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. ERC-2018 CoG-816564 ActionContraThreat). M.M. and D.R.B. receive support from the National Institute for Health Research (NIHR) UCLH Biomedical Research Centre. M.G.M. was supported by a research grant from the Swedish Research Council (VR521-2013-2589).

Keywords

adolescence
computational psychiatry
decision acuity
development
functional connectivity

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuron.2021.04.019Licence: CC BY

Cite this

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title = "Decision-making ability, psychopathology, and brain connectivity",

abstract = "Decision-making is a cognitive process of central importance for the quality of our lives. Here, we ask whether a common factor underpins our diverse decision-making abilities. We obtained 32 decision-making measures from 830 young people and identified a common factor that we call “decision acuity,” which was distinct from IQ and reflected a generic decision-making ability. Decision acuity was decreased in those with aberrant thinking and low general social functioning. Crucially, decision acuity and IQ had dissociable brain signatures, in terms of their associated neural networks of resting-state functional connectivity. Decision acuity was reliably measured, and its relationship with functional connectivity was also stable when measured in the same individuals 18 months later. Thus, our behavioral and brain data identify a new cognitive construct that underpins decision-making ability across multiple domains. This construct may be important for understanding mental health, particularly regarding poor social function and aberrant thought patterns.",

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author = "{NSPN Consortium} and Michael Moutoussis and Benjam{\'i}n Garz{\'o}n and Sharon Neufeld and Bach, {Dominik R.} and Francesco Rigoli and Ian Goodyer and Edward Bullmore and Peter Fonagy and Peter Jones and Tobias Hauser and Rafael Romero-Garcia and {St Clair}, Michelle and Petra V{\'e}rtes and Kirstie Whitaker and Becky Inkster and Gita Prabhu and Cinly Ooi and Umar Toseeb and Barry Widmer and Junaid Bhatti and Laura Villis and Ayesha Alrumaithi and Sarah Birt and Aislinn Bowler and Kalia Cleridou and Hina Dadabhoy and Emma Davies and Ashlyn Firkins and Sian Granville and Elizabeth Harding and Alexandra Hopkins and Daniel Isaacs and Janchai King and Danae Kokorikou and Christina Maurice and Cleo McIntosh and Jessica Memarzia and Harriet Mills and Ciara O'Donnell and Sara Pantaleone and Jenny Scott and Pasco Fearon and John Suckling and {van Harmelen}, {Anne Laura} and Rogier Kievit and Marc Guitart-Masip and Dolan, {Raymond J.}",

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AU - Toseeb, Umar

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Decision-making ability, psychopathology, and brain connectivity

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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