Darolutamide in hormone-sensitive and castration-resistant prostate cancer

Valeria Emma Palmieri, Giandomenico Roviello, Alberto D'Angelo, Chiara Casadei, Ugo De Giorgi, Roberta Giorgione

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Important changes in the treatment of prostate cancer have taken place in recent years. Non-metastatic castration-resistant prostate cancer (nmCRPC) has been clinically delineated. In this setting, three drugs have been approved in high-risk disease: apalutamide, enzalutamide and darolutamide.Areas covered:This manuscript aims to profile darolutamide, its clinical development, pharmacologic properties, efficacy and safety. We presented the results of published clinical studies, but we also investigated ongoing ones.Expert opinion: An indirect comparison with the other two aforementioned drugs emerged. While the clinical efficacy is comparable, the toxicity profile is different for darolutamide, resulting in greater tolerance. We must wait for the results of the trials that study darolutamide in hormone-sensitive disease, both in the metastatic phase and in the localized phase. Clinical experience will also be important to determine ever more personalized treatments for patients.

Original languageEnglish
Pages (from-to)535-544
Number of pages10
JournalExpert Review of Clinical Pharmacology
Volume14
Issue number5
Early online date21 Mar 2021
DOIs
Publication statusPublished - 31 Dec 2021

Keywords

  • Darolutamide
  • androgen receptor antagonist
  • castration-resistant
  • hormone-sensitive
  • non-metastatic
  • prostate cancer

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

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