D-Fructose-L-sorbose interconversions. Access to 5-thio-D-fructose and interaction with the D-fructose transporter, GLUT5

A Tatibouet, M Lefoix, J Nadolny, O R Martin, P Rollin, J Yang, G D Holman

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Epimerisation and subsequent functionalization at C-5 of D-fructopyranose derivatives under Mitsunobu and Garegg's conditions provided efficient access to 5-thio-D-fructose (2) as well as to 5-azido-5-deoxy-1,2-O-isopropylidene-beta -D-fructopyranose (19), a known precursor to 2,5-deoxy-2,5-imino-D-mannitol (3). The interaction of 2 with the D-fructose transporter GLUTS, was found to be weaker than that of D-fructose, a result that suggests involvement of the ring oxygen atom in the recognition of D-fructose by GLUTS. (C) 2001 Elsevier Science Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalCarbohydrate Research
Volume333
Issue number4
Publication statusPublished - 2001

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