Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification

Kirstin Scherlach; Hans-Wilhelm Nuetzmann; Volker Schroeckh; Hans-Martin Dahse; Axel A Brakhage; Christian Hertweck

doi:10.1002/anie.201104488

Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification

Kirstin Scherlach, Hans-Wilhelm Nuetzmann, Volker Schroeckh, Hans-Martin Dahse, Axel A Brakhage, Christian Hertweck

Department of Life Sciences

Leibniz Institute for Natural Product Research and Infection Biology (HKI)

Research output: Contribution to journal › Article › peer-review

39 Citations (SciVal)

Abstract

What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.

Original language	English
Pages (from-to)	9843-7
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	50
Issue number	42
DOIs	https://doi.org/10.1002/anie.201104488
Publication status	Published - 10 Oct 2011

Keywords

Antineoplastic Agents
Aspergillus nidulans
Benzopyrans
Biological Products
Cell Proliferation
Cytotoxins
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Endothelium, Vascular
Fungal Proteins
Genetic Engineering
HeLa Cells
Heterocyclic Compounds
Humans
K562 Cells
Molecular Structure
Mutation
Protein Processing, Post-Translational
Structure-Activity Relationship
Thiazines
Journal Article
Research Support, Non-U.S. Gov't

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10.1002/anie.201104488

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title = "Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification",

abstract = "What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.",

keywords = "Antineoplastic Agents, Aspergillus nidulans, Benzopyrans, Biological Products, Cell Proliferation, Cytotoxins, Dose-Response Relationship, Drug, Drug Screening Assays, Antitumor, Endothelium, Vascular, Fungal Proteins, Genetic Engineering, HeLa Cells, Heterocyclic Compounds, Humans, K562 Cells, Molecular Structure, Mutation, Protein Processing, Post-Translational, Structure-Activity Relationship, Thiazines, Journal Article, Research Support, Non-U.S. Gov't",

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T1 - Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification

AU - Scherlach, Kirstin

AU - Nuetzmann, Hans-Wilhelm

AU - Schroeckh, Volker

AU - Dahse, Hans-Martin

AU - Brakhage, Axel A

AU - Hertweck, Christian

PY - 2011/10/10

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N2 - What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.

AB - What makes a fungus blush? The deletion of a gene that is required for global protein N-acetylation triggers the production of unprecedented metabolites in Aspergillus nidulans. The pronounced red pigmentation of the engineered mutant is caused by pheofungins (benzothiazinone chromophores), the biogenesis of which is strikingly similar to those of pheomelanins found in red bird feathers and hair of Celtic origin.

KW - Antineoplastic Agents

KW - Aspergillus nidulans

KW - Benzopyrans

KW - Biological Products

KW - Cell Proliferation

KW - Cytotoxins

KW - Dose-Response Relationship, Drug

KW - Drug Screening Assays, Antitumor

KW - Endothelium, Vascular

KW - Fungal Proteins

KW - Genetic Engineering

KW - HeLa Cells

KW - Heterocyclic Compounds

KW - Humans

KW - K562 Cells

KW - Molecular Structure

KW - Mutation

KW - Protein Processing, Post-Translational

KW - Structure-Activity Relationship

KW - Thiazines

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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DO - 10.1002/anie.201104488

M3 - Article

C2 - 21913294

SN - 1433-7851

VL - 50

SP - 9843

EP - 9847

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 42

ER -

Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification

Abstract

Keywords

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