Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor

Jules L Hammond, Andrew Gross, Pedro Estrela, Jesus Iniesta, Stephen J. Green, C Peter Winlove, Peter G. Winyard, Nigel Benjamin, Frank Marken

Research output: Contribution to journalArticle

18 Citations (Scopus)
59 Downloads (Pure)

Abstract

Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold–gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels.
Original languageEnglish
Pages (from-to)6748-6752
Number of pages5
JournalAnalytical Chemistry
Volume86
Issue number14
Early online date23 Jun 2014
DOIs
Publication statusPublished - 15 Jul 2014

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Cystine
Gold
Cysteine
Sensors
Electrodes
Sulfhydryl Compounds
Disulfides
Amplification
Buffers
Feedback
Adsorption
Oxidation-Reduction

Cite this

Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor. / Hammond, Jules L; Gross, Andrew; Estrela, Pedro; Iniesta, Jesus; Green, Stephen J.; Winlove, C Peter; Winyard, Peter G.; Benjamin, Nigel; Marken, Frank.

In: Analytical Chemistry, Vol. 86, No. 14, 15.07.2014, p. 6748-6752.

Research output: Contribution to journalArticle

Hammond, JL, Gross, A, Estrela, P, Iniesta, J, Green, SJ, Winlove, CP, Winyard, PG, Benjamin, N & Marken, F 2014, 'Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor', Analytical Chemistry, vol. 86, no. 14, pp. 6748-6752. https://doi.org/10.1021/ac501321e
Hammond, Jules L ; Gross, Andrew ; Estrela, Pedro ; Iniesta, Jesus ; Green, Stephen J. ; Winlove, C Peter ; Winyard, Peter G. ; Benjamin, Nigel ; Marken, Frank. / Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor. In: Analytical Chemistry. 2014 ; Vol. 86, No. 14. pp. 6748-6752.
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