Cysteine-cystine redox cycling in a gold-gold dual-plate generator-collector microtrench sensor

Jules L Hammond, Andrew Gross, Pedro Estrela, Jesus Iniesta, Stephen J. Green, C Peter Winlove, Peter G. Winyard, Nigel Benjamin, Frank Marken

Research output: Contribution to journalArticle

20 Citations (Scopus)
128 Downloads (Pure)

Abstract

Thiols and disulfides are ubiquitous and important analytical targets. However, their redox properties, in particular on gold sensor electrodes, are complex and obscured by strong adsorption. Here, a gold–gold dual-plate microtrench dual-electrode sensor with feedback signal amplification is demonstrated to give well-defined (but kinetically limited) steady-state voltammetric current responses for the cysteine-cystine redox cycle in nondegassed aqueous buffer media at pH 7 down to micromolar concentration levels.
Original languageEnglish
Pages (from-to)6748-6752
Number of pages5
JournalAnalytical Chemistry
Volume86
Issue number14
Early online date23 Jun 2014
DOIs
Publication statusPublished - 15 Jul 2014

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