Cyclometalated Complexes of Platinum and Palladium with N-(4-Chlorophenyl)-α-benzoylbenzylideneamine. in Vitro Cytostatic Activity, DNA Modification, and Interstrand Cross-Link Studies

Carmen Navarro-Ranninger, Isabel López-Solera, Víctor M. González, José M. Pérez, Amparo Alvarez-Valdés, Avelino Martín, Paul R. Raithby, José R. Masaguer, Carlos Alonso

Research output: Contribution to journalArticlepeer-review


In the present paper we report the synthesis and structural IR and 1H and 13C NMR characterization of four platinum(II) and palladium(II) cyclometalated complexes of the formula [Pd(4-ClC6H4N=C(COC6H5)C 6H4)X]2, where X = OAc (2) or Cl (3), and [Pt(4-ClC6H4N=C(COC6H5)C 6H4)X]2, where X = Cl (4) or OAc (5). The acetate-bridged compounds 2 and 5 have an open-book structure. The chloro-bridged compounds 3 and 4 have an unfolded structure. Complex 2 crystallizes in the centrosymmetric triclinic space group P1̄, with Z = 2. Unit cell parameters are as follows: a = 11.765(3) Å,b = 12.862(4) Å, c = 15.022(5) Å, α = 84.08(2)°, β= 78.56(2)°, γ = 83.13(2)°. All these compounds were screened against MDA-MB 468 (breast carcinoma) and HL-60 (leukemic) tumor cells. The low IC50 values of compound 5 (1.05 μM) and of compound 4 (1.58 μM) against MDA-MB 468 and of 0.82 μM (5) and 1.37 μM (4) against HL-60 relative to cis-DDP (2.67 and 2.07 μM, respectively) and other cyclometalated compounds suggest that the synthesized compounds may be regarded as having potential antitumor properties. The data suggest that the antiproliferative activity of compound 5 may correlate with its covalent binding to DNA and the induction of important modifications on the helix.

Original languageEnglish
Pages (from-to)5181-5187
Number of pages7
JournalInorganic Chemistry
Issue number18
Publication statusPublished - 28 Aug 1996

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

Cite this