Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity

Barry Potter; Andreas H Guse; Hendrik Schulze-Koops; Ingeborg Berg; Georg W Mayr

Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity

Barry Potter (Inventor), Andreas H Guse (Inventor), Hendrik Schulze-Koops (Inventor), Ingeborg Berg (Inventor), Georg W Mayr (Inventor)

Department of Life Sciences

Research output: Patent

Abstract

Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.

Original language	English
Patent number	WO0037089 (A1)
IPC	G01N33/50, A61K31/70
Priority date	18/12/98
Publication status	Published - 29 Jun 2000

Cite this

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title = "Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity",

abstract = "Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.",

author = "Barry Potter and Guse, \{Andreas H\} and Hendrik Schulze-Koops and Ingeborg Berg and Mayr, \{Georg W\}",

year = "2000",

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day = "29",

language = "English",

type = "Patent",

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T1 - Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity

AU - Potter, Barry

AU - Guse, Andreas H

AU - Schulze-Koops , Hendrik

AU - Berg , Ingeborg

AU - Mayr, Georg W

PY - 2000/6/29

Y1 - 2000/6/29

N2 - Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.

AB - Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.

UR - https://worldwide.espacenet.com/patent/search/family/010844606/publication/WO0037089A1?q=pn%3DEP1140118A1

M3 - Patent

M1 - WO0037089 (A1)

ER -

Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity

Abstract

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