Abstract
Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.
Original language | English |
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Patent number | WO0037089 (A1) |
IPC | G01N33/50, A61K31/70 |
Priority date | 18/12/98 |
Publication status | Published - 29 Jun 2000 |