Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.
|Patent number||WO0037089 (A1)|
|Publication status||Published - 29 Jun 2000|
Potter, B., Guse, A. H., Schulze-Koops , H., Berg , I., & Mayr, G. W. (2000). IPC No. G01N33/50. Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity. (Patent No. WO0037089 (A1)).