Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity

Barry Potter (Inventor), Andreas H Guse (Inventor), Hendrik Schulze-Koops (Inventor), Ingeborg Berg (Inventor), Georg W Mayr (Inventor)

Research output: Patent

Abstract

Compounds capable of antagonising a sustained cADPR-mediated rise in intracellular Ca<2+> levels in a T cell, said rise being in response to stimulation of the T cell receptor/CD3 complex of the T cell, methods for identifying the same and their use in modulating T cell activity are described. The preferred compounds are cyclic adenosine diphosphate ribose analogues.
Original languageEnglish
Patent numberWO0037089 (A1)
IPCG01N33/50
Publication statusPublished - 29 Jun 2000

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Potter, B., Guse, A. H., Schulze-Koops , H., Berg , I., & Mayr, G. W. (2000). IPC No. G01N33/50. Cyclic Adenosine Diphosphate Ribose Analogues for Modulating T Cell Activity. (Patent No. WO0037089 (A1)).