Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer

Navid Sobhani, Anna Ianza, Alberto D'Angelo, Giandomenico Roviello, Fabiola Giudici, Marina Bortul, Fabrizio Zanconati, Cristina Bottin, Daniele Generali

Research output: Contribution to journalReview article

Abstract

Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis. In an era of personalized medicine, there is an urgent need for better knowledge of the biology leading to the disease, which can lead to the design of increasingly accurate drugs against patients' specific molecular aberrations. Among one of the actionable targets is the fibroblast growth factor receptor (FGFR) pathway, triggered by specific ligands. The Fibroblast Growth Factor Receptors/Fibroblast Growth Factors (FGFRs/FGFs) axis offers interesting molecular targets to be pursued in clinical development. This mini-review will focus on the current knowledge of FGFR mutations, which lead to tumor formation and summarizes the state-of-the-art therapeutic strategies for targeted treatments against the FGFRs/FGFs axis in the context of BC.

Original languageEnglish
Article number76
JournalStem Cells
Volume7
Issue number7
DOIs
Publication statusPublished - 15 Jul 2018

Cite this

Sobhani, N., Ianza, A., D'Angelo, A., Roviello, G., Giudici, F., Bortul, M., ... Generali, D. (2018). Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer. Stem Cells, 7(7), [76]. https://doi.org/10.3390/cells7070076

Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer. / Sobhani, Navid; Ianza, Anna; D'Angelo, Alberto; Roviello, Giandomenico; Giudici, Fabiola; Bortul, Marina; Zanconati, Fabrizio; Bottin, Cristina; Generali, Daniele.

In: Stem Cells, Vol. 7, No. 7, 76, 15.07.2018.

Research output: Contribution to journalReview article

Sobhani, N, Ianza, A, D'Angelo, A, Roviello, G, Giudici, F, Bortul, M, Zanconati, F, Bottin, C & Generali, D 2018, 'Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer', Stem Cells, vol. 7, no. 7, 76. https://doi.org/10.3390/cells7070076
Sobhani, Navid ; Ianza, Anna ; D'Angelo, Alberto ; Roviello, Giandomenico ; Giudici, Fabiola ; Bortul, Marina ; Zanconati, Fabrizio ; Bottin, Cristina ; Generali, Daniele. / Current Status of Fibroblast Growth Factor Receptor-Targeted Therapies in Breast Cancer. In: Stem Cells. 2018 ; Vol. 7, No. 7.
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AU - Zanconati, Fabrizio

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AB - Breast cancer (BC) is the most common malignancy and second only to lung cancer in terms of mortality in women. Despite the incredible progress made in this field, metastatic breast cancer has a poor prognosis. In an era of personalized medicine, there is an urgent need for better knowledge of the biology leading to the disease, which can lead to the design of increasingly accurate drugs against patients' specific molecular aberrations. Among one of the actionable targets is the fibroblast growth factor receptor (FGFR) pathway, triggered by specific ligands. The Fibroblast Growth Factor Receptors/Fibroblast Growth Factors (FGFRs/FGFs) axis offers interesting molecular targets to be pursued in clinical development. This mini-review will focus on the current knowledge of FGFR mutations, which lead to tumor formation and summarizes the state-of-the-art therapeutic strategies for targeted treatments against the FGFRs/FGFs axis in the context of BC.

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