Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review

Oliver O'Sullivan; Peter Ladlow; Kat Steiner; Charles Hillman; Joanne Stocks; Alexander N. Bennett; Ana M. Valdes; Stefan Kluzek

doi:10.1016/j.ocarto.2023.100412

Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review

Oliver O'Sullivan, Peter Ladlow, Kat Steiner, Charles Hillman, Joanne Stocks, Alexander N. Bennett, Ana M. Valdes, Stefan Kluzek

Department for Health

Research output: Contribution to journal › Review article › peer-review

4 Citations (SciVal)

Abstract

Post-traumatic OA (PTOA) can occur within 5 years after a significant injury and is a valuable paradigm for identifying biomarkers. This systematic review aims to summarise published literature in human studies on the associations of known serum and synovial fluid biomarkers at least a year from injury to structural, symptomatic changes and underlying PTOA processes. A systematic review was performed using PRISMA guidelines, prospectively registered on PROSPERO (CRD42022371838), for all ‘wet’ biomarkers a year or more post-injury in 18–45-year-old participants. Three independent reviewers screened search results, extracted data, and performed risk of bias assessments (Newcastle-Ottawa Scale). Study heterogeneity meant a narrative synthesis was undertaken, utilising SWiM guidelines. 952 studies were identified, 664 remaining after deduplication. Following first-round screening, 53 studies underwent second-round screening against pre-determined criteria. Eight studies, with 879 participants (49 % male), were included, measuring serum (n = 7), synovial fluid (SF, n = 6), or both (n = 5). The pooled participant mean age was 29.1 (±4). 51 biomarkers were studied (serum = 38, SF = 13), with no correlation between paired serum and SF samples. One serum biomarker, cartilage oligomeric matrix protein (COMP), and four SF biomarkers, interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF), and COMP, were measured in multiple studies. Associations were described between 11 biomarkers related to catabolism (n = 4), anabolism (n = 2), inflammation (n = 4) and non-coding RNA (n = 1), with OA imaging changes (X-ray and MRI), pain, quality of life and function. Widespread differences in study design and methodology prevented meta-analysis, and evidence was generally weak. A unified approach is required before widespread research and clinical biomarker use.

Original language	English
Article number	100412
Number of pages	10
Journal	Osteoarthritis and Cartilage Open
Volume	5
Issue number	4
Early online date	5 Oct 2023
DOIs	https://doi.org/10.1016/j.ocarto.2023.100412
Publication status	Published - 31 Dec 2023

Bibliographical note

Funding Information:
This work was supported by a grant from Versus Arthritis (21076) and funding from the UK Ministry of Defence (2122.030). Funders were not involved in the preparation or publication of this work.

Funding

This work was supported by a grant from Versus Arthritis (21076) and funding from the UK Ministry of Defence (2122.030). Funders were not involved in the preparation or publication of this work.

Keywords

Biomarkers
Pathophysiology
Post-traumatic osteoarthritis
Serum
Synovial fluid

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Rehabilitation
Biomedical Engineering

Access to Document

10.1016/j.ocarto.2023.100412Licence: CC BY

Cite this

O'Sullivan, O., Ladlow, P., Steiner, K., Hillman, C., Stocks, J., Bennett, A. N., Valdes, A. M., & Kluzek, S. (2023). Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review. Osteoarthritis and Cartilage Open, 5(4), Article 100412. https://doi.org/10.1016/j.ocarto.2023.100412

Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review. / O'Sullivan, Oliver; Ladlow, Peter; Steiner, Kat et al.
In: Osteoarthritis and Cartilage Open, Vol. 5, No. 4, 100412, 31.12.2023.

Research output: Contribution to journal › Review article › peer-review

O'Sullivan, O, Ladlow, P, Steiner, K, Hillman, C, Stocks, J, Bennett, AN, Valdes, AM & Kluzek, S 2023, 'Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review', Osteoarthritis and Cartilage Open, vol. 5, no. 4, 100412. https://doi.org/10.1016/j.ocarto.2023.100412

O'Sullivan O, Ladlow P, Steiner K, Hillman C, Stocks J, Bennett AN et al. Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review. Osteoarthritis and Cartilage Open. 2023 Dec 31;5(4):100412. Epub 2023 Oct 5. doi: 10.1016/j.ocarto.2023.100412

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Current status of catabolic, anabolic and inflammatory biomarkers associated with structural and symptomatic changes in the chronic phase of post-traumatic knee osteoarthritis– a systematic review

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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