TY - JOUR
T1 - Current insights on the effects of medicinal plants in the management of obesity and infectious diseases
T2 - An update from 2020
AU - Ofoezie, Ezichi Favour
AU - Ogbonna, Chinwendu Angela
AU - George, Ezinne Tiffany
AU - Anunobi, Chioma Juliet
AU - Olisakwe, Sandra C.
AU - Babarinde, Simeon
AU - Chukwuemeka, Chidera Godson
AU - Ogbonna, Uzochukwu Eric
AU - Amafili, Chibuzo Collette
AU - Omaba, Justina Onyinyechi
AU - Ogbonna, Henry Nnaemeka
PY - 2025/6/30
Y1 - 2025/6/30
N2 - Medicinal plants have long played a pivotal role in traditional medicine, and their integration into modern healthcare is gaining recognition for their potential in treating a range of conditions, including obesity and infectious diseases. Their bioactive compounds offer a natural, sustainable alternative to synthetic drugs, with significant therapeutic benefits. This review focuses on the recent advances of medicinal plants in addressing two major global health challenges: obesity and infectious diseases. In modern medicine, these plants are valued for their ability to manage weight by influencing metabolic processes such as fat oxidation, insulin sensitivity, and inflammation. Additionally, their antimicrobial properties offer effective solutions against drug-resistant pathogens, presenting a complementary approach to conventional treatments. Through a comprehensive analysis of bioactive compounds, the review investigates their mechanisms, including enzyme inhibition, modulation of immune response, and disruption of microbial growth and biofilm formation. Key findings indicate that these phytochemicals demonstrate both anti-obesity and antimicrobial activities, with potential to reduce inflammation, improve metabolic health, and combat drug-resistant infections. In essence, medicinal plants hold significant promise as natural therapeutic agents for managing obesity and infectious diseases. Their ability to target multiple biological pathways simultaneously makes them effective in addressing the complex interplay between metabolic disorders and immune dysfunction.
AB - Medicinal plants have long played a pivotal role in traditional medicine, and their integration into modern healthcare is gaining recognition for their potential in treating a range of conditions, including obesity and infectious diseases. Their bioactive compounds offer a natural, sustainable alternative to synthetic drugs, with significant therapeutic benefits. This review focuses on the recent advances of medicinal plants in addressing two major global health challenges: obesity and infectious diseases. In modern medicine, these plants are valued for their ability to manage weight by influencing metabolic processes such as fat oxidation, insulin sensitivity, and inflammation. Additionally, their antimicrobial properties offer effective solutions against drug-resistant pathogens, presenting a complementary approach to conventional treatments. Through a comprehensive analysis of bioactive compounds, the review investigates their mechanisms, including enzyme inhibition, modulation of immune response, and disruption of microbial growth and biofilm formation. Key findings indicate that these phytochemicals demonstrate both anti-obesity and antimicrobial activities, with potential to reduce inflammation, improve metabolic health, and combat drug-resistant infections. In essence, medicinal plants hold significant promise as natural therapeutic agents for managing obesity and infectious diseases. Their ability to target multiple biological pathways simultaneously makes them effective in addressing the complex interplay between metabolic disorders and immune dysfunction.
KW - Infectious disease
KW - Mechanism
KW - Medicinal plants
KW - Obesity
KW - Phytochemicals
UR - http://www.scopus.com/inward/record.url?scp=105001364951&partnerID=8YFLogxK
U2 - 10.1016/j.amolm.2025.100075
DO - 10.1016/j.amolm.2025.100075
M3 - Review article
AN - SCOPUS:105001364951
SN - 2949-6888
VL - 5
JO - Aspects of Molecular Medicine
JF - Aspects of Molecular Medicine
M1 - 100075
ER -
