Current and Future Outlook on Disease Modification and Defining Low Disease Activity in Systemic Sclerosis

Vivek Nagaraja, Marco Matucci-Cerinic, Daniel E. Furst, Masataka Kuwana, Yannick Allanore, Christopher P. Denton, Ganesh Raghu, Vallerie Mclaughlin, Panduranga S. Rao, James R. Seibold, John D. Pauling, Michael L. Whitfield, Dinesh Khanna

Research output: Contribution to journalArticlepeer-review

28 Citations (SciVal)


Systemic sclerosis (SSc) is an autoimmune rheumatic disease with heterogeneous clinical manifestations and a variable course in which the severity of the pathology dictates the disease prognosis and course. Among autoimmune rheumatic diseases, SSc has the highest mortality rate among all rheumatic diseases, though there are exciting new therapeutic targets that appear to halt the progression of SSc manifestations such as skin or lung fibrosis. In selected patients, high-intensity regimens with autologous stem cell transplantation can favorably modify the course. In what was once thought to be an untreatable disease, targeted therapies have now changed the outlook of SSc to a treatable disorder. Herein, we discuss the targeted therapies modifying the outlook on selected organ involvement and creating opportunities for future treatment. We also present a framework for defining low disease activity in SSc.

Original languageEnglish
Pages (from-to)1049-1058
Number of pages10
JournalArthritis and Rheumatology
Issue number7
Early online date5 Mar 2020
Publication statusPublished - 1 Jul 2020

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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