Cu(II) homogeneous and heterogeneous catalysts for the asymmetric Henry reaction

Matthew Jones, Christine Cooper, Mary F Mahon, Paul R Raithby, D Apperley, J Wolowska, D Collison

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

New Cu(II) complexes have been prepared and characterised via single crystal X-ray diffraction studies, EPR spectroscopy, elemental analysis and high resolution mass spectrometry. In all cases 1:2 (copper to ligand) stoichiometric complexes were isolated. The homogeneous Cu(II) complexes were tested for the asymmetric Henry reaction. Conversions in excess of 70% were obtained with enantioselectivities in the range 0-78%. Heterogeneous Cu(II) catalysts have been prepared. In these cases high conversions were obtained. However, after prolonged reaction time the main product observed was 1,3-dinitro-2-phenyl propane. The formation of this product can be curtailed by both decreasing the catalyst loading and employing shorter reaction times.
Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalJournal of Molecular Catalysis A: Chemical
Volume325
Issue number1-2
DOIs
Publication statusPublished - 15 Jun 2010

Keywords

  • supported catalysts
  • homogeneous and heterogeneous catalysts
  • copper

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