Projects per year
Several soil-derived Actinobacteria produce secondary metabolites that are proven specific and potent inhibitors of the human angiotensin-I-converting enzyme (ACE), a key target for the modulation of hypertension through its role in the renin–angiotensin–aldosterone system. K-26-DCP is a zinc dipeptidyl carboxypeptidase (DCP) produced by Astrosporangium hypotensionis, and an ancestral homologue of ACE. Here we report the high-resolution crystal structures of K-26-DCP and of its complex with the natural microbial tripeptide product K-26. The experimental results provide the structural basis for better understanding the specificity of K-26 for human ACE over bacterial DCPs. Database: Structural data are available in the PDB under the accession numbers 5L43 and 5L44.
- angiotensin-I-converting enzyme
- dipeptidyl carboxypeptidase
- K-26 tripeptide
FingerprintDive into the research topics of 'Crystal structure of a peptidyl-dipeptidase K-26-DCP from <i>Actinomycete</i> in complex with its natural inhibitor'. Together they form a unique fingerprint.
- 1 Finished
1/02/16 → 30/04/20
Project: Research council