Abstract
6-[(l-methyl-4-nitroimidazol-5-yl)thio] purine, is an immunosuppressant derivative of the antitumour drug, 6-mercaptopurine. Crystals are monoclinic with a = 4.488(2), b = 31.886(4), c = 8.067(2)A and β= 105.99(2)° in the space group P21/c. The crystal structure was solved by direct methods using diffractometer data and refined by least squares to an R- index of 0.065 for 502 observed reflections. The molecule crystallizes in the N(9)-H tautomer form, in contrast to the N(7)-H tautomer form found in crystals of 6-mercaptopurine and assume a conformation in which the substituents on the sulphur atom are directed away from imidazole moiety of the purine
| Original language | English |
|---|---|
| Pages (from-to) | 183-187 |
| Number of pages | 5 |
| Journal | Proceedings of the Indian Academy of Sciences - Chemical Sciences |
| Volume | 93 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Mar 1984 |
Keywords
- crystal structure
- direct methods
- immunosuppressor
- Mercaptopurine
ASJC Scopus subject areas
- General Chemistry