Cryptic ecology among host generalist Campylobacter jejuni in domestic animals

Samuel K. Sheppard, Lu Cheng, Guillaume Meric, Caroline P. A. de Haan, Ann-Katrin Llarena, Pekka Marttinen, Ana Vidal, Anne Ridley, Felicity Clifton-Hadley, Thomas R. Connor, Norval J. C. Strachan, Ken Forbes, Frances M. Colles, Keith A. Jolley, Stephen D Bentley, Martin C. J. Maiden, Marja-Liisa Hanninen, Julian Parkhill, William P. Hanage, Jukka Corander

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57 Citations (Scopus)

Abstract

Homologous recombination between bacterial strains is theoretically capable of preventing the separation of daughter clusters, and producing cohesive clouds of genotypes in sequence space. However, numerous barriers to recombination are known. Barriers may be essential such as adaptive incompatibility, or ecological, which is associated with the opportunities for recombination in the natural habitat. Campylobacter jejuni is a gut colonizer of numerous animal species and a major human enteric pathogen. We demonstrate that the two major generalist lineages of C. jejuni do not show evidence of recombination with each other in nature, despite having a high degree of host niche overlap and recombining extensively with specialist lineages. However, transformation experiments show that the generalist lineages readily recombine with one another in vitro. This suggests ecological rather than essential barriers to recombination, caused by a cryptic niche structure within the hosts.
Original languageEnglish
Pages (from-to)2442-2451
Number of pages10
JournalMolecular Ecology
Volume23
Issue number10
Early online date1 Apr 2014
DOIs
Publication statusPublished - 15 May 2014

Keywords

  • Adaption
  • Campylobacter
  • Genomics
  • Recombination barriers

Cite this

Sheppard, S. K., Cheng, L., Meric, G., de Haan, C. P. A., Llarena, A-K., Marttinen, P., Vidal, A., Ridley, A., Clifton-Hadley, F., Connor, T. R., Strachan, N. J. C., Forbes, K., Colles, F. M., Jolley, K. A., Bentley, S. D., Maiden, M. C. J., Hanninen, M-L., Parkhill, J., Hanage, W. P., & Corander, J. (2014). Cryptic ecology among host generalist Campylobacter jejuni in domestic animals. Molecular Ecology, 23(10), 2442-2451. https://doi.org/10.1111/mec.12742