Cross-talk between imprinted loci in Prader-Willi syndrome

A. Murrell

doi:10.1038/ng.2994

Cross-talk between imprinted loci in Prader-Willi syndrome

A. Murrell

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (SciVal)

Abstract

Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important implications for the understanding of imprinted gene networks.

Original language	English
Pages (from-to)	528-530
Number of pages	3
Journal	Nature Genetics
Volume	46
Issue number	6
Early online date	28 May 2014
DOIs	https://doi.org/10.1038/ng.2994
Publication status	Published - Jun 2014

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10.1038/ng.2994

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abstract = "Prader-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chromosome 15, including the long noncoding RNA IPW. A new study identifies a critical role for IPW in modulating the expression of maternally expressed genes in trans, which has important implications for the understanding of imprinted gene networks.",

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Cross-talk between imprinted loci in Prader-Willi syndrome

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