Craniofacial shape transition across the house mouse hybrid zone

implications for the genetic architecture and evolution of between-species differences

Luisa F Pallares, Leslie M Turner, Diethard Tautz

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Craniofacial shape differences between taxa have often been linked to environmental adaptation, e.g., new food sources, or have been studied in the context of domestication. Evidence for the genetic basis of such phenotypic differences to date suggests that between-species as well as between-population variation has an oligogenic basis, i.e., few loci of large effect explain most of the variation. In mice, it has been shown that within-population craniofacial variation has a highly polygenic basis, but there are no data regarding the genetic basis of between-species differences in natural populations. Here, we address this question using a phenotype-focused approach. Using 3D geometric morphometrics, we phenotyped a panel of mice derived from a natural hybrid zone between Mus musculus domesticus and Mus mus musculus and quantify the transition of craniofacial shape along the hybridization gradient. We find a continuous shape transition along the hybridization gradient and unaltered developmental stability associated with hybridization. This suggests that the morphospace between the two subspecies is continuous despite reproductive isolation and strong barriers to gene flow. We show that quantitative changes in overall genome composition generate quantitative changes in craniofacial shape; this supports a highly polygenic basis for between-species craniofacial differences in the house mouse. We discuss our findings in the context of oligogenic versus polygenic models of the genetic architecture of morphological traits.

Original languageEnglish
Pages (from-to)173-186
Number of pages14
JournalDevelopment Genes and Evolution
Volume226
Issue number3
DOIs
Publication statusPublished - Jun 2016

Fingerprint

hybrid zone
Molecular Evolution
Mus musculus
interspecific variation
hybridization
developmental stability
Mus
domestication
reproductive isolation
mice
Reproductive Isolation
Population
subspecies
gene flow
phenotype
Gene Flow
genome
Genetic Models
loci
food

Keywords

  • Journal Article

Cite this

@article{38200409401c4eda85b90e091b32a4ae,
title = "Craniofacial shape transition across the house mouse hybrid zone: implications for the genetic architecture and evolution of between-species differences",
abstract = "Craniofacial shape differences between taxa have often been linked to environmental adaptation, e.g., new food sources, or have been studied in the context of domestication. Evidence for the genetic basis of such phenotypic differences to date suggests that between-species as well as between-population variation has an oligogenic basis, i.e., few loci of large effect explain most of the variation. In mice, it has been shown that within-population craniofacial variation has a highly polygenic basis, but there are no data regarding the genetic basis of between-species differences in natural populations. Here, we address this question using a phenotype-focused approach. Using 3D geometric morphometrics, we phenotyped a panel of mice derived from a natural hybrid zone between Mus musculus domesticus and Mus mus musculus and quantify the transition of craniofacial shape along the hybridization gradient. We find a continuous shape transition along the hybridization gradient and unaltered developmental stability associated with hybridization. This suggests that the morphospace between the two subspecies is continuous despite reproductive isolation and strong barriers to gene flow. We show that quantitative changes in overall genome composition generate quantitative changes in craniofacial shape; this supports a highly polygenic basis for between-species craniofacial differences in the house mouse. We discuss our findings in the context of oligogenic versus polygenic models of the genetic architecture of morphological traits.",
keywords = "Journal Article",
author = "Pallares, {Luisa F} and Turner, {Leslie M} and Diethard Tautz",
year = "2016",
month = "6",
doi = "10.1007/s00427-016-0550-7",
language = "English",
volume = "226",
pages = "173--186",
journal = "Development Genes and Evolution",
issn = "0949-944X",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Craniofacial shape transition across the house mouse hybrid zone

T2 - implications for the genetic architecture and evolution of between-species differences

AU - Pallares, Luisa F

AU - Turner, Leslie M

AU - Tautz, Diethard

PY - 2016/6

Y1 - 2016/6

N2 - Craniofacial shape differences between taxa have often been linked to environmental adaptation, e.g., new food sources, or have been studied in the context of domestication. Evidence for the genetic basis of such phenotypic differences to date suggests that between-species as well as between-population variation has an oligogenic basis, i.e., few loci of large effect explain most of the variation. In mice, it has been shown that within-population craniofacial variation has a highly polygenic basis, but there are no data regarding the genetic basis of between-species differences in natural populations. Here, we address this question using a phenotype-focused approach. Using 3D geometric morphometrics, we phenotyped a panel of mice derived from a natural hybrid zone between Mus musculus domesticus and Mus mus musculus and quantify the transition of craniofacial shape along the hybridization gradient. We find a continuous shape transition along the hybridization gradient and unaltered developmental stability associated with hybridization. This suggests that the morphospace between the two subspecies is continuous despite reproductive isolation and strong barriers to gene flow. We show that quantitative changes in overall genome composition generate quantitative changes in craniofacial shape; this supports a highly polygenic basis for between-species craniofacial differences in the house mouse. We discuss our findings in the context of oligogenic versus polygenic models of the genetic architecture of morphological traits.

AB - Craniofacial shape differences between taxa have often been linked to environmental adaptation, e.g., new food sources, or have been studied in the context of domestication. Evidence for the genetic basis of such phenotypic differences to date suggests that between-species as well as between-population variation has an oligogenic basis, i.e., few loci of large effect explain most of the variation. In mice, it has been shown that within-population craniofacial variation has a highly polygenic basis, but there are no data regarding the genetic basis of between-species differences in natural populations. Here, we address this question using a phenotype-focused approach. Using 3D geometric morphometrics, we phenotyped a panel of mice derived from a natural hybrid zone between Mus musculus domesticus and Mus mus musculus and quantify the transition of craniofacial shape along the hybridization gradient. We find a continuous shape transition along the hybridization gradient and unaltered developmental stability associated with hybridization. This suggests that the morphospace between the two subspecies is continuous despite reproductive isolation and strong barriers to gene flow. We show that quantitative changes in overall genome composition generate quantitative changes in craniofacial shape; this supports a highly polygenic basis for between-species craniofacial differences in the house mouse. We discuss our findings in the context of oligogenic versus polygenic models of the genetic architecture of morphological traits.

KW - Journal Article

UR - http://dx.doi.org/10.1007/s00427-016-0550-7

UR - http://dx.doi.org/10.1007/s00427-016-0550-7

U2 - 10.1007/s00427-016-0550-7

DO - 10.1007/s00427-016-0550-7

M3 - Article

VL - 226

SP - 173

EP - 186

JO - Development Genes and Evolution

JF - Development Genes and Evolution

SN - 0949-944X

IS - 3

ER -