Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

Luling Wu, Xue Tian, Robin R. Groleau, Jie Wang, Hai Hao Han, Shaun B. Reeksting, Adam C. Sedgwick, Xiao Peng He, Steven D. Bull, Tony D. James

Research output: Contribution to journalArticle


A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO- and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO- analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

Original languageEnglish
Pages (from-to)13496-13499
Number of pages4
JournalRSC Advances
Issue number23
Early online date3 Apr 2020
Publication statusPublished - 2020

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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