Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

Luling Wu; Xue Tian; Robin R. Groleau; Jie Wang; Hai Hao Han; Shaun B. Reeksting; Adam C. Sedgwick; Xiao Peng He; Steven D. Bull; Tony D. James

doi:10.1039/d0ra02234a

Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

Luling Wu, Xue Tian, Robin R. Groleau, Jie Wang, Hai Hao Han, Shaun B. Reeksting, Adam C. Sedgwick, Xiao Peng He, Steven D. Bull, Tony D. James

Research output: Contribution to journal › Article › peer-review

12 Citations (SciVal)

Abstract

A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO^- and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO^- analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

Original language	English
Pages (from-to)	13496-13499
Number of pages	4
Journal	RSC Advances
Volume	10
Issue number	23
Early online date	3 Apr 2020
DOIs	https://doi.org/10.1039/d0ra02234a
Publication status	Published - 2020

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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10.1039/d0ra02234aLicence: CC BY

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title = "Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols",

abstract = "A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO- and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO- analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.",

author = "Luling Wu and Xue Tian and Groleau, {Robin R.} and Jie Wang and Han, {Hai Hao} and Reeksting, {Shaun B.} and Sedgwick, {Adam C.} and He, {Xiao Peng} and Bull, {Steven D.} and James, {Tony D.}",

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T1 - Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

AU - Wu, Luling

AU - Tian, Xue

AU - Groleau, Robin R.

AU - Wang, Jie

AU - Han, Hai Hao

AU - Reeksting, Shaun B.

AU - Sedgwick, Adam C.

AU - He, Xiao Peng

AU - Bull, Steven D.

AU - James, Tony D.

PY - 2020

Y1 - 2020

N2 - A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO- and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO- analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

AB - A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO- and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO- analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

UR - http://www.scopus.com/inward/record.url?scp=85083451015&partnerID=8YFLogxK

U2 - 10.1039/d0ra02234a

DO - 10.1039/d0ra02234a

M3 - Article

AN - SCOPUS:85083451015

SN - 2046-2069

VL - 10

SP - 13496

EP - 13499

JO - RSC Advances

JF - RSC Advances

IS - 23

ER -

Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

Abstract

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