Coumarin-based fluorescent probe for the rapid detection of peroxynitrite 'AND' biological thiols

Luling Wu, Xue Tian, Robin R. Groleau, Jie Wang, Hai Hao Han, Shaun B. Reeksting, Adam C. Sedgwick, Xiao Peng He, Steven D. Bull, Tony D. James

Research output: Contribution to journalArticlepeer-review

15 Citations (SciVal)

Abstract

A coumarin-based novel 'AND' logic fluorescent probe ROS-AHC has been developed for the simultaneous detection of ONOO- and biological thiols. ROS-AHC was shown to exhibit only a very small fluorescence response upon addition of a single GSH or ONOO- analyte. Exposure to both analytes, however, resulted in a significant fluorescence enhancement.

Original languageEnglish
Pages (from-to)13496-13499
Number of pages4
JournalRSC Advances
Volume10
Issue number23
Early online date3 Apr 2020
DOIs
Publication statusPublished - 2020

Funding

LW wishes to thank China Scholarship Council and the University of Bath for supporting his PhD work in the UK. We would like to thank the EPSRC and the University of Bath for funding. X.-P. He thanks the National Natural Science Foundation of China (21722801, 21788102 and 91853201). RRG wishes to thank the EPSRC Centre for Doctoral Training in Catalysis for funding and support (EP/L016443/1). TDJ wishes to thank the Royal Society for a Wolfson Research Merit Award. NMR characterisation facilities were provided through the Materials and Chemical Characterisation Facility (MC2) at the University of Bath (www.bath.ac.uk/research-facilities/material-and-chemical-characterisation-facility-mc2). The EPSRC UK National Mass Spectrometry Facility at Swansea University is thanked for analyses. All data supporting this study are provided as ESI† accompanying this paper.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering

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