Corticosteroid switch after progression on abiraterone acetate plus prednisone

Giandomenico Roviello, Navid Sobhani, Silvia Paola Corona, Alberto D'Angelo

Research output: Contribution to journalReview article

Abstract

INTRODUCTION: Abiraterone acetate plus prednisone is approved in metastatic castration-resistant prostate cancer. There is some evidence in favour of the steroid switch from prednisone to dexamethasone in patients who progressed whilst on abiraterone acetate plus prednisone or prednisolone.

MATERIALS AND METHODS: The aim of this review is to discuss the results from the clinical studies available, examining potential mechanisms of action and patient selection criteria for this treatment option.

RESULTS: A total of four studies were evaluated. Among possible eligibility criteria for steroid switch, we found: PSA progression without any radiological or clinical progression during abiraterone acetate + prednisone; no high-grade adverse events related to CYP-17 inhibition; and unfitness for chemotherapy or radium-223.

CONCLUSION: Although large randomized prospective trials are warranted, steroid switch seems to offer a good option for certain patients treated with abiraterone acetate plus prednisone or prednisolone.

Original languageEnglish
Number of pages7
JournalInternational Journal of Clinical Oncology
Early online date8 Nov 2019
DOIs
Publication statusE-pub ahead of print - 8 Nov 2019

Keywords

  • Abiraterone
  • Dexamethasone
  • Prednisone
  • Switch

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

Cite this

Corticosteroid switch after progression on abiraterone acetate plus prednisone. / Roviello, Giandomenico; Sobhani, Navid; Corona, Silvia Paola; D'Angelo, Alberto.

In: International Journal of Clinical Oncology, 08.11.2019.

Research output: Contribution to journalReview article

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N2 - INTRODUCTION: Abiraterone acetate plus prednisone is approved in metastatic castration-resistant prostate cancer. There is some evidence in favour of the steroid switch from prednisone to dexamethasone in patients who progressed whilst on abiraterone acetate plus prednisone or prednisolone.MATERIALS AND METHODS: The aim of this review is to discuss the results from the clinical studies available, examining potential mechanisms of action and patient selection criteria for this treatment option.RESULTS: A total of four studies were evaluated. Among possible eligibility criteria for steroid switch, we found: PSA progression without any radiological or clinical progression during abiraterone acetate + prednisone; no high-grade adverse events related to CYP-17 inhibition; and unfitness for chemotherapy or radium-223.CONCLUSION: Although large randomized prospective trials are warranted, steroid switch seems to offer a good option for certain patients treated with abiraterone acetate plus prednisone or prednisolone.

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