Core-shell spheroidal hydrogels produced via charge-driven interfacial complexation

Vincenzo Calabrese, Davide Califano, Marcelo Alves Da Silva, Julien Schmitt, Saffron Jade Bryant, Kazi M. Zakir Hossain, Ana Maria Percebom, Aurora Perez-gramatges, Janet Lesley Scott, Karen J. Edler

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)


Through charge-driven interfacial complexation, we produced millimetre-sized spheroidal hydrogels (SH) with a core-shell structure allowing long term stability in aqueous media. The SH were fabricated by extruding, drop-wise, a cationic cellulose nanofibril (CCNF) dispersion into an oppositely charged polyacrylic acid (PAA) bath. The SH have a solid-like CCNF-PAA shell, acting as a semi-permeable membrane, and a liquid-like CCNF suspension in the core. Swelling behaviour of the SH was dependent on the osmotic pressure of the ageing media. Swelling could be supressed by increasing the ionic strength of the media as this enhanced interfibrillar interactions and thus strengthened the outer gel membrane. We further validated a potential application of SH as re-usable matrixes for glucose oxidase (GOx) entrapment, where the SH work as “microreactors” from which substrate and product are freely able to migrate, through the SH shell whilst avoiding enzyme leakage.
Original languageEnglish
Pages (from-to)1213-1221
Number of pages9
JournalACS Applied Polymer Materials
Issue number3
Early online date12 Feb 2020
Publication statusPublished - 13 Mar 2020


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