Copper(I) tris(pyrazolyl)borate complexes for use in positron emission tomograhpy

Steven Kealey, L E Jennings, P W Miller, A D Gee, C Plisson, A J P White, Stephen Husbands, N J Long

Research output: Contribution to journalArticlepeer-review

Abstract

[11C]Carbon monoxide is a versatile radiolabelling reagent for the synthesis of 11C‐labelled tracer molecules for use in positron emission tomography (PET) medical imaging. However, the use of this reagent is hampered by its poor solubility in organic solvents and its delivery at high dilution in an inert gas stream, thus lowering its reactivity, as well as the practical difficulties encountered when working with ionising radiation. Copper(I) complexes supported by tris(pyrazolyl)borate ligands (also known as ‘scorpionate’ ligands, Figure 1) have proved to be an effective means of solubilising [11C]CO gas through the formation of the corresponding copper(I)[11C]carbonyl complexes, allowing [11C]CO to be effectively ‘trapped’ in solution (Figure 2).12 These solutions have been used as the [11C]CO source for subsequent palladium‐mediated carbonylation reactions to form 11C‐labelled amides and ureas. The coordination chemistry of a series of tris(pyrazolyl)borate ligands bearing appended donor groups (phosphine, phosphine oxide, pyridyl, thioether) tethered to the pyrazolyl rings has been explored and their reactivity with copper(I) and [12C]CO and [11C]CO examined.
Original languageEnglish
Pages (from-to)392-392
Number of pages1
JournalJournal of Labelled Compounds & Radiopharmaceuticals
Volume54
Issue number7
DOIs
Publication statusPublished - Jun 2011
Event19th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2010 - Cambridge, UK United Kingdom
Duration: 14 Oct 2010 → …

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