Copper, zinc and tin 3-hydroxypyridinones

Marie C. Barret, Purvi H. Bhatia, Gabriele Kociok-Köhn, Kieran C. Molloy

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Abstract

A series of copper(II) [R = Me, R′ = Me (14), Et (15), n-Bu (16), Bz (17), Menth (18); R = Et, R′ = Me (19), Et (20), n-Bu (21), Bz (22)] and zinc(II) [R = Me, R′ = Me (23), Et (24), n-Bu (25), Bz (26), Menth (27); R = Et, R′ = Me (28), Et (29), n-Bu (30), Bz (31)] bis-hydroxypyridinones have been prepared from the ligands (HL) 2-R, N-R′ hydroxypyridinone [R = Me, R′ = Me (1), Et (2), n-Bu (3), Bz (4), Menth (13); R = Et, R′ = Me (5), Et (6), n-Bu (7), Bz (8)]. Attempts to prepare similar tin(II) species from SnCl2 resulted in isolation of Sn(L)Cl (L = 1–8). The structures of the metal complexes 18.0.25acetone, 21, 22.2MeOH, 26.2H2O, 28.H2O have been determined. Antimicrobial testing against S. warneri shows the ligands (1–8) and their zinc derivatives (23–26, 28–31) have no or little activity while the copper complexes (14–17, 19–22) show significant activity. The menthyl-substituted analogues (13, 18, 27) are the most active of their respective series.

Original languageEnglish
Pages (from-to)241-254
JournalTransition Metal Chemistry
Volume40
Issue number3
Early online date31 Jan 2015
DOIs
Publication statusPublished - 4 Apr 2015

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Tin
Zinc
Copper
Ligands
Coordination Complexes
Metal complexes
Derivatives
Testing

Cite this

Barret, M. C., Bhatia, P. H., Kociok-Köhn, G., & Molloy, K. C. (2015). Copper, zinc and tin 3-hydroxypyridinones. Transition Metal Chemistry, 40(3), 241-254. https://doi.org/10.1007/s11243-015-9912-7

Copper, zinc and tin 3-hydroxypyridinones. / Barret, Marie C.; Bhatia, Purvi H.; Kociok-Köhn, Gabriele; Molloy, Kieran C.

In: Transition Metal Chemistry, Vol. 40, No. 3, 04.04.2015, p. 241-254.

Research output: Contribution to journalArticle

Barret, MC, Bhatia, PH, Kociok-Köhn, G & Molloy, KC 2015, 'Copper, zinc and tin 3-hydroxypyridinones', Transition Metal Chemistry, vol. 40, no. 3, pp. 241-254. https://doi.org/10.1007/s11243-015-9912-7
Barret MC, Bhatia PH, Kociok-Köhn G, Molloy KC. Copper, zinc and tin 3-hydroxypyridinones. Transition Metal Chemistry. 2015 Apr 4;40(3):241-254. https://doi.org/10.1007/s11243-015-9912-7
Barret, Marie C. ; Bhatia, Purvi H. ; Kociok-Köhn, Gabriele ; Molloy, Kieran C. / Copper, zinc and tin 3-hydroxypyridinones. In: Transition Metal Chemistry. 2015 ; Vol. 40, No. 3. pp. 241-254.
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