Projects per year
Abstract
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)(2) (1-2 mol %) was found to be effective for this transformation at 80 C. The reaction was successful with either conventional or microwave heating. CuO and CuO/ZnO on activated carbon provided a competent reuseable heterogeneous catalyst which could be used in a batch process or in flow. Copper salts are much cheaper than the precious metals previously used for this rearrangement, and the reaction conditions are milder than those reported.
Original language | English |
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Pages (from-to) | 4252-4255 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 52 |
Issue number | 33 |
DOIs | |
Publication status | Published - 17 Aug 2011 |
Keywords
- sustainable chemistry
- amide
- copper
- synthetic methods
- rearrangement
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Dive into the research topics of 'Copper-catalyzed rearrangement of oximes into primary amides'. Together they form a unique fingerprint.Projects
- 1 Finished
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New Generic Synthetic Protocols for Pharmaceutical Intermediates
Williams, J. (PI), Lapkin, A. (CoI), Plucinski, P. (CoI) & Price, R. (CoI)
Engineering and Physical Sciences Research Council
1/07/09 → 16/05/13
Project: Research council
Equipment
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MC2- Nuclear Magnetic Resonance (NMR)
Material and Chemical Characterisation (MC2)Facility/equipment: Technology type