Projects per year
The atom-efficient and cost-effective rearrangement of oximes into primary amides is catalyzed by simple copper salts. The use of homogeneous Cu(OAc)(2) (1-2 mol %) was found to be effective for this transformation at 80 C. The reaction was successful with either conventional or microwave heating. CuO and CuO/ZnO on activated carbon provided a competent reuseable heterogeneous catalyst which could be used in a batch process or in flow. Copper salts are much cheaper than the precious metals previously used for this rearrangement, and the reaction conditions are milder than those reported.
|Number of pages||4|
|Publication status||Published - 17 Aug 2011|
- sustainable chemistry
- synthetic methods
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- 1 Finished
New Generic Synthetic Protocols for Pharmaceutical Intermediates
Williams, J., Lapkin, A., Plucinski, P. & Price, R.
Engineering and Physical Sciences Research Council
1/07/09 → 16/05/13
Project: Research council
MC2- Nuclear Magnetic Resonance (NMR)Material and Chemical Characterisation (MC2)
Facility/equipment: Technology type