Copper-catalyzed one-pot synthesis of  N-Aryl oxazolidinones from amino alcohol carbamates

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Abstract

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

Original languageEnglish
Pages (from-to)5020-5023
Number of pages4
JournalOrganic Letters
Volume16
Issue number19
Early online date16 Sep 2014
DOIs
Publication statusPublished - 2 Oct 2014

Fingerprint

Amino Alcohols
Oxazolidinones
Carbamates
Iodides
iodides
Copper
alcohols
copper
synthesis
Nitriles
Halogens
Ethers
Cyclization
cross coupling
nitriles
Ketones
ketones
halogens
ethers

Cite this

Copper-catalyzed one-pot synthesis of  N-Aryl oxazolidinones from amino alcohol carbamates. / Mahy, W.; Plucinski, P.K.; Frost, C.G.

In: Organic Letters, Vol. 16, No. 19, 02.10.2014, p. 5020-5023.

Research output: Contribution to journalArticle

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