Copper-catalyzed one-pot synthesis of  N-Aryl oxazolidinones from amino alcohol carbamates

W. Mahy; P.K. Plucinski; C.G. Frost

doi:10.1021/ol502322c

Copper-catalyzed one-pot synthesis of N-Aryl oxazolidinones from amino alcohol carbamates

W. Mahy, P.K. Plucinski, C.G. Frost

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Abstract

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

Original language	English
Pages (from-to)	5020-5023
Number of pages	4
Journal	Organic Letters
Volume	16
Issue number	19
Early online date	16 Sept 2014
DOIs	https://doi.org/10.1021/ol502322c
Publication status	Published - 2 Oct 2014

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10.1021/ol502322c

Copper catalysed
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Organic Letteres, copyright © American Chemical Society after peer review. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/ol502322c.
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abstract = "An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.",

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N2 - An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

AB - An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

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Copper-catalyzed one-pot synthesis of N-Aryl oxazolidinones from amino alcohol carbamates

Abstract

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