Copper-catalyzed one-pot synthesis of  N-Aryl oxazolidinones from amino alcohol carbamates

W. Mahy, P.K. Plucinski, C.G. Frost

Research output: Contribution to journalArticle

29 Citations (Scopus)
119 Downloads (Pure)

Abstract

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

Original languageEnglish
Pages (from-to)5020-5023
Number of pages4
JournalOrganic Letters
Volume16
Issue number19
Early online date16 Sep 2014
DOIs
Publication statusPublished - 2 Oct 2014

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