Conversion of aldoximes into nitriles and amides under mild conditions

K. Tambara, G. D Pantos

Research output: Contribution to journalArticlepeer-review

44 Citations (SciVal)


A series of Pd(en)X2 salts were used as catalysts for the conversion of aldoximes into nitriles and amides. Highlights of this protocol include the use of inexpensive polar solvents, including water, and moderate reaction temperatures. A high degree of selectivity in the reaction outcome was observed when using aliphatic vs. aromatic/conjugated aldoximes.

Original languageEnglish
Pages (from-to)2466-2472
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number15
Early online date12 Feb 2013
Publication statusPublished - 21 Apr 2013


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