Conversion of Alcohols into Amines by Borrowing Hydrogen

Malai H S A Hamid

Research output: ThesisDoctoral Thesis

Abstract

This thesis describes the development of a more economical catalytic system for the N-alkylation of amines by “borrowing hydrogen” and its application in the synthesis of a variety of amines including the dopamine agonist Piribedil and the antihistamine agents Antergan and Tripelennamine. Chapter 2 describes the development of the ruthenium-catalysed N-alkylation of primary amines with primary alcohols by “borrowing hydrogen”. Chapter 3 describes the application of the ruthenium-catalysed N-alkylation of secondary amines with primary alcohols by “borrowing hydrogen”. The ruthenium-catalysed synthesis of dimethylamines by “borrowing hydrogen” is also described and a mechanistic proposal for the N-alkylation of alcohols with amines has been proposed. Chapter 4 describes the role of amines in pharmaceuticals and the ruthenium-catalysed synthesis of Piribedil, Antergan and Tripelennamine by “borrowing hydrogen”.
LanguageEnglish
QualificationPh.D.
Awarding Institution
  • University of Bath
Supervisors/Advisors
  • Williams, Julian, Supervisor, External person
Award date1 Nov 2008
StatusUnpublished - Jun 2008

Fingerprint

Amines
Hydrogen
Ruthenium
Alcohols
Alkylation
Tripelennamine
Piribedil
Cyproheptadine
Dimethylamines
Histamine Antagonists
Dopamine Agonists
Pharmaceutical Preparations

Keywords

  • catalysis
  • amination
  • N-Alkylation
  • Amines
  • ruthenium

Cite this

Conversion of Alcohols into Amines by Borrowing Hydrogen. / Hamid, Malai H S A.

2008. 187 p.

Research output: ThesisDoctoral Thesis

Hamid, MHSA 2008, 'Conversion of Alcohols into Amines by Borrowing Hydrogen', Ph.D., University of Bath.
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AB - This thesis describes the development of a more economical catalytic system for the N-alkylation of amines by “borrowing hydrogen” and its application in the synthesis of a variety of amines including the dopamine agonist Piribedil and the antihistamine agents Antergan and Tripelennamine. Chapter 2 describes the development of the ruthenium-catalysed N-alkylation of primary amines with primary alcohols by “borrowing hydrogen”. Chapter 3 describes the application of the ruthenium-catalysed N-alkylation of secondary amines with primary alcohols by “borrowing hydrogen”. The ruthenium-catalysed synthesis of dimethylamines by “borrowing hydrogen” is also described and a mechanistic proposal for the N-alkylation of alcohols with amines has been proposed. Chapter 4 describes the role of amines in pharmaceuticals and the ruthenium-catalysed synthesis of Piribedil, Antergan and Tripelennamine by “borrowing hydrogen”.

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KW - amination

KW - N-Alkylation

KW - Amines

KW - ruthenium

M3 - Doctoral Thesis

ER -