Abstract
Antimicrobial resistance is one of the greatest threats to human health. Gram-positive methicillin resistant Staphylococcus aureus (MRSA), in both its planktonic and biofilm form, is of particular concern. Herein we identify the hydrogelation properties for a series of intrinsically fluorescent, structurally related supramolecular self-associating amphiphiles and determine their efficacy against both planktonic and biofilm forms of MRSA. To further explore the potential translation of this hydrogel technology for real-world applications, the toxicity of the amphiphiles was determined against the eukaryotic multicellular model organism, Caenorhabditis elegans. Due to the intrinsic fluorescent nature of these supramolecular amphiphiles, material characterisation of their molecular self-associating properties included; comparative optical density plate reader assays, rheometry and widefield fluorescence microscopy. This enabled determination of amphiphile structure and hydrogel sol dependence on resultant fibre formation.
| Original language | English |
|---|---|
| Pages (from-to) | 3958-3968 |
| Number of pages | 11 |
| Journal | Journal of Materials Chemistry B |
| Volume | 11 |
| Issue number | 17 |
| Early online date | 12 Apr 2023 |
| DOIs | |
| Publication status | Published - 7 May 2023 |
Bibliographical note
Funding Information:KLFH, LJW and JRH would like to thank the University of Kent for funding. AAK would like to thank the GCDC for funding. KLFH and JRH would like to thank Dr John Stolz for his help reviewing this document. LJW and JRH would also like to thank the UKRI (MR/T020415/1) for funding.
Funding
KLFH, LJW and JRH would like to thank the University of Kent for funding. AAK would like to thank the GCDC for funding. KLFH and JRH would like to thank Dr John Stolz for his help reviewing this document. LJW and JRH would also like to thank the UKRI (MR/T020415/1) for funding.
ASJC Scopus subject areas
- General Chemistry
- Biomedical Engineering
- General Materials Science
