Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K-and GSK-3-dependent signalling

Melanie J Welham, Emmajayne Kingham, Yolanda Sanchez Ripoll, Benjamin Kumpfmueller, Michael Storm, Heather Bone

Research output: Contribution to journalArticle

25 Citations (Scopus)
149 Downloads (Pure)

Abstract

ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the generation of specific cell types for use in regenerative medicine and drug screening. In order to harness their potential, the molecular mechanisms regulating ESC pluripotency, proliferation and differentiation (i.e. cell fate) need to be understood so that pluripotency can be maintained during expansion, while differentiation to specific lineages can be induced accurately when required. The present review focuses on the potential roles that PI3K (phosphoinositide 3-kinase) and GSK-3 (glycogen synthase kinase 3)-dependent signalling play in the co-ordination and integration of mouse ESC pluripotency and proliferation and contrast this with our understanding of their functions in human ESCs.
Original languageEnglish
Pages (from-to)674-678
Number of pages5
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2011

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