Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Lauren Agnew; Charles Wilson; Dyanne Cruickshank; Thomas McGlone

doi:10.1039/C6CC01032F

Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Lauren Agnew
, Charles Wilson
, Dyanne Cruickshank
, Thomas McGlone

University of Cape Town
University of Strathclyde

Research output: Contribution to journal › Article › peer-review

42 Citations (SciVal)

Abstract

A scalable, transferable, cooling crystallisation route to the elusive,
metastable, form II of the API acetaminophen (paracetamol) has
been developed using a multicomponent ‘‘templating’’ approach,
delivering 100% polymorphic phase pure form II at scales up to
120 g. Favourable solubility and stability properties are found for
the form II samples.

Original language	English
Pages (from-to)	7368-7371
Number of pages	7371
Journal	Chemical Communications
Volume	52
Early online date	19 Feb 2016
DOIs	https://doi.org/10.1039/C6CC01032F
Publication status	Published - 2016

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10.1039/C6CC01032FLicence: CC BY

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abstract = "A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent {\textquoteleft}{\textquoteleft}templating{\textquoteright}{\textquoteright} approach, delivering 100\% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.",

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AU - Agnew, Lauren

AU - Wilson, Charles

AU - Cruickshank, Dyanne

AU - McGlone, Thomas

PY - 2016

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N2 - A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent ‘‘templating’’ approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

AB - A scalable, transferable, cooling crystallisation route to the elusive, metastable, form II of the API acetaminophen (paracetamol) has been developed using a multicomponent ‘‘templating’’ approach, delivering 100% polymorphic phase pure form II at scales up to 120 g. Favourable solubility and stability properties are found for the form II samples.

UR - http://dx.doi.org/10.1039/C6CC01032F

U2 - 10.1039/C6CC01032F

DO - 10.1039/C6CC01032F

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JO - Chemical Communications

JF - Chemical Communications

ER -

Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Abstract

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