Abstract
A scalable, transferable, cooling crystallisation route to the elusive,
metastable, form II of the API acetaminophen (paracetamol) has
been developed using a multicomponent ‘‘templating’’ approach,
delivering 100% polymorphic phase pure form II at scales up to
120 g. Favourable solubility and stability properties are found for
the form II samples.
metastable, form II of the API acetaminophen (paracetamol) has
been developed using a multicomponent ‘‘templating’’ approach,
delivering 100% polymorphic phase pure form II at scales up to
120 g. Favourable solubility and stability properties are found for
the form II samples.
Original language | English |
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Pages (from-to) | 7368-7371 |
Number of pages | 7371 |
Journal | Chemical Communications |
Volume | 52 |
Early online date | 19 Feb 2016 |
DOIs | |
Publication status | Published - 2016 |