Controlled production of the elusive metastable form II of acetaminophen (paracetamol): a fully scalable templating approach in a cooling environment

Lauren Agnew, Charles Wilson, Dyanne Cruickshank, Thomas McGlone

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A scalable, transferable, cooling crystallisation route to the elusive,
metastable, form II of the API acetaminophen (paracetamol) has
been developed using a multicomponent ‘‘templating’’ approach,
delivering 100% polymorphic phase pure form II at scales up to
120 g. Favourable solubility and stability properties are found for
the form II samples.
Original languageEnglish
Pages (from-to)7368-7371
Number of pages7371
JournalChemical Communications
Volume52
Early online date19 Feb 2016
DOIs
Publication statusPublished - 2016

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