Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors

Bo Zheng; Fengwei Xie; Wenbei Situ; Ling Chen; Xiaoxi Li

doi:10.1016/j.jff.2017.07.048

Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors

Bo Zheng, Fengwei Xie, Wenbei Situ, Ling Chen, Xiaoxi Li

Research output: Contribution to journal › Article › peer-review

7 Citations (SciVal)

Abstract

A new carrier system for controlled release of immunologic peptides based on double polysaccharide film-coated microparticles (PCMPs) used with liquid products was developed. The release behavior of PCMPs was shown dependent on the thicknesses of the outer chitosan film and the inner resistant starch acetate (RSA) film. The in-vitro release results indicated that, with optimized polysaccharide coating thickness (RSA: 4–5%; chitosan: 6–7%), the release rate of Thymopoietin (TP5) was less than 30% before the microparticles reached the colon, and was 50% in the colon. Besides, the bioavailability of PCMPs was evaluated based on the cell proliferation and protein expression. Compared with the intraperitoneal injection or oral administration, the immunodeficient rats that were orally administrated with the yogurt containing TP5-loaded PCMPs with different storage times possessed a good colon-targeting behavior, higher ratios of CD4/CD8 and IgG expression, indicating the improvement in the TP5 immunologic function.

Original language	English
Pages (from-to)	272-282
Number of pages	11
Journal	Journal of Functional Foods
Volume	37
DOIs	https://doi.org/10.1016/j.jff.2017.07.048
Publication status	Published - 1 Oct 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Funding

This research has been financially supported under the National Natural Science Foundation of China (NSFC)-Guangdong Joint Foundation Key Project (U1501214), YangFan Innovative and Entrepreneurial Research Team Project (2014YT02S029), the R&D Projects of Guangdong Province (2014B090904047), the Science and Technology Program of Guangzhou (201607010109), the Key R&D Projects of Zhongshan (2014A2FC217), the innovative projects for Universities in Guangdong Province (2015KTSCX006), and the Fundamental Research Funds for the Central Universities (2015ZZ106).

Funders	Funder number
Key R&D Projects of Zhongshan	2014A2FC217
R&D Projects of Guangdong Province	2014B090904047
YangFan Innovative and Entrepreneurial Research Team Project	2014YT02S029
National Natural Science Foundation of China	U1501214
Guangzhou Science and Technology Program key projects	201607010109
Fundamental Research Funds for the Central Universities	2015ZZ106
innovative projects for Universities in Guangdong Province	2015KTSCX006

Keywords

Chitosan
Colon-targeting
Controlled release
Liquid products
pH-responsiveness
Resistant starch acetate

ASJC Scopus subject areas

Food Science
Medicine (miscellaneous)
Nutrition and Dietetics

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10.1016/j.jff.2017.07.048

Cite this

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title = "Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors",

abstract = "A new carrier system for controlled release of immunologic peptides based on double polysaccharide film-coated microparticles (PCMPs) used with liquid products was developed. The release behavior of PCMPs was shown dependent on the thicknesses of the outer chitosan film and the inner resistant starch acetate (RSA) film. The in-vitro release results indicated that, with optimized polysaccharide coating thickness (RSA: 4–5%; chitosan: 6–7%), the release rate of Thymopoietin (TP5) was less than 30% before the microparticles reached the colon, and was 50% in the colon. Besides, the bioavailability of PCMPs was evaluated based on the cell proliferation and protein expression. Compared with the intraperitoneal injection or oral administration, the immunodeficient rats that were orally administrated with the yogurt containing TP5-loaded PCMPs with different storage times possessed a good colon-targeting behavior, higher ratios of CD4/CD8 and IgG expression, indicating the improvement in the TP5 immunologic function.",

keywords = "Chitosan, Colon-targeting, Controlled release, Liquid products, pH-responsiveness, Resistant starch acetate",

author = "Bo Zheng and Fengwei Xie and Wenbei Situ and Ling Chen and Xiaoxi Li",

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AU - Zheng, Bo

AU - Xie, Fengwei

AU - Situ, Wenbei

AU - Chen, Ling

AU - Li, Xiaoxi

PY - 2017/10/1

Y1 - 2017/10/1

N2 - A new carrier system for controlled release of immunologic peptides based on double polysaccharide film-coated microparticles (PCMPs) used with liquid products was developed. The release behavior of PCMPs was shown dependent on the thicknesses of the outer chitosan film and the inner resistant starch acetate (RSA) film. The in-vitro release results indicated that, with optimized polysaccharide coating thickness (RSA: 4–5%; chitosan: 6–7%), the release rate of Thymopoietin (TP5) was less than 30% before the microparticles reached the colon, and was 50% in the colon. Besides, the bioavailability of PCMPs was evaluated based on the cell proliferation and protein expression. Compared with the intraperitoneal injection or oral administration, the immunodeficient rats that were orally administrated with the yogurt containing TP5-loaded PCMPs with different storage times possessed a good colon-targeting behavior, higher ratios of CD4/CD8 and IgG expression, indicating the improvement in the TP5 immunologic function.

AB - A new carrier system for controlled release of immunologic peptides based on double polysaccharide film-coated microparticles (PCMPs) used with liquid products was developed. The release behavior of PCMPs was shown dependent on the thicknesses of the outer chitosan film and the inner resistant starch acetate (RSA) film. The in-vitro release results indicated that, with optimized polysaccharide coating thickness (RSA: 4–5%; chitosan: 6–7%), the release rate of Thymopoietin (TP5) was less than 30% before the microparticles reached the colon, and was 50% in the colon. Besides, the bioavailability of PCMPs was evaluated based on the cell proliferation and protein expression. Compared with the intraperitoneal injection or oral administration, the immunodeficient rats that were orally administrated with the yogurt containing TP5-loaded PCMPs with different storage times possessed a good colon-targeting behavior, higher ratios of CD4/CD8 and IgG expression, indicating the improvement in the TP5 immunologic function.

KW - Chitosan

KW - Colon-targeting

KW - Controlled release

KW - Liquid products

KW - pH-responsiveness

KW - Resistant starch acetate

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Controlled bioactive compound delivery systems based on double polysaccharide film-coated microparticles for liquid products and their release behaviors

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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