Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

J P Spencer, H Schroeter, A J Crossthwaithe, G Kuhnle, Robert J Williams, C Rice-Evans

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.
Original languageEnglish
Pages (from-to)1139-46
Number of pages8
JournalFree Radical Biology and Medicine
Volume31
Issue number9
DOIs
Publication statusPublished - 2001

Fingerprint Dive into the research topics of 'Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts'. Together they form a unique fingerprint.

  • Cite this