Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

J P Spencer; H Schroeter; A J Crossthwaithe; G Kuhnle; Robert J Williams; C Rice-Evans

doi:10.1016/S0891-5849(01)00704-3

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

J P Spencer, H Schroeter, A J Crossthwaithe, G Kuhnle, Robert J Williams, C Rice-Evans

Department of Life Sciences

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148 Citations (SciVal)

Abstract

The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.

Original language	English
Pages (from-to)	1139-46
Number of pages	8
Journal	Free Radical Biology and Medicine
Volume	31
Issue number	9
DOIs	https://doi.org/10.1016/S0891-5849(01)00704-3
Publication status	Published - 2001

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10.1016/S0891-5849(01)00704-3

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title = "Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts",

abstract = "The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.",

author = "Spencer, {J P} and H Schroeter and Crossthwaithe, {A J} and G Kuhnle and Williams, {Robert J} and C Rice-Evans",

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AU - Spencer, J P

AU - Schroeter, H

AU - Crossthwaithe, A J

AU - Kuhnle, G

AU - Williams, Robert J

AU - Rice-Evans, C

PY - 2001

Y1 - 2001

N2 - The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.

AB - The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.

UR - http://dx.doi.org/10.1016/S0891-5849(01)00704-3

U2 - 10.1016/S0891-5849(01)00704-3

DO - 10.1016/S0891-5849(01)00704-3

M3 - Article

C2 - 11677047

SN - 0891-5849

VL - 31

SP - 1139

EP - 1146

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

IS - 9

ER -

Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

Abstract

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