Continuous endocytic recycling of tight junction proteins: how and why?

Andrew Chalmers, Paul Whitley

Research output: Contribution to journalArticle

17 Citations (Scopus)
134 Downloads (Pure)

Abstract

Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic structures that are able to maintain barrier function during tissue remodelling and rapidly alter it in response to extracellular signals. Individual components of tight junctions also show dynamic behaviour, including migration within the junction and exchange in and out of the junctions. In addition, it is becoming clear that some tight junction proteins undergo continuous endocytosis and recycling back to the plasma membrane. Regulation of endocytic trafficking of junctional proteins may provide a way of rapidly remodelling junctions and will be the focus of this chapter.
Original languageEnglish
Pages (from-to)41-54
Number of pages14
JournalEssays in Biochemistry
Volume53
DOIs
Publication statusPublished - 2012

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