Continuous endocytic recycling of tight junction proteins: how and why?

Research output: Contribution to journalArticle

  • 14 Citations

Abstract

Tight junctions consist of many proteins, including transmembrane and associated cytoplasmic proteins, which act to provide a barrier regulating transport across epithelial and endothelial tissues. These junctions are dynamic structures that are able to maintain barrier function during tissue remodelling and rapidly alter it in response to extracellular signals. Individual components of tight junctions also show dynamic behaviour, including migration within the junction and exchange in and out of the junctions. In addition, it is becoming clear that some tight junction proteins undergo continuous endocytosis and recycling back to the plasma membrane. Regulation of endocytic trafficking of junctional proteins may provide a way of rapidly remodelling junctions and will be the focus of this chapter.
LanguageEnglish
Pages41-54
Number of pages14
JournalEssays in Biochemistry
Volume53
DOIs
StatusPublished - 2012

Fingerprint

Tight Junction Proteins
Tight Junctions
Recycling
Protein Transport
Endocytosis
Tissue
Endothelium
Proteins
Epithelium
Cell Membrane
Cell membranes

Cite this

Continuous endocytic recycling of tight junction proteins: how and why? / Chalmers, Andrew; Whitley, Paul.

In: Essays in Biochemistry, Vol. 53, 2012, p. 41-54.

Research output: Contribution to journalArticle

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