Contamination within trials of community-based public health interventions: lessons from the HENRY feasibility study

Elizabeth Stamp, Holly Schofield, Victoria Laurina Roberts, Wendy Burton, Michelle Collinson, June Stevens, Amanda Farrin, Harry Rutter, Maria Bryant

Research output: Contribution to journalArticlepeer-review

Abstract

Contamination occurs when participants allocated to trial control arms receive elements of the active intervention. Randomisation at cluster level, rather than individual level, may reduce or eliminate contamination, avoiding the dilution of intervention effectiveness that it may cause. However, cluster randomisation can result in selection bias and may not be feasible to deliver. We explored the extent of contamination in a qualitative study nested within a feasibility study of HENRY (Health, Exercise and Nutrition for the Really Young); a UK community-based child obesity prevention programme. We aimed to determine the nature and impact of contamination to inform a larger planned trial and other trials in community based public health settings.
Original languageEnglish
JournalPilot and Feasibility Studies
Volume7
Issue number1
DOIs
Publication statusPublished - 26 Mar 2021

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