Abstract
Cu(I)-catalyzed coupling of lactams with (E)-2-chlorovinyl iodides or (E)-2-bromovinyl iodides produces the corresponding β-halo enamides in moderate to excellent yields. E.g., in the presence of CuI and MeNHCH2CH2NHMe, coupling of (E)-2-chlorovinyl iodide I with lactam II gave 43% β-halo enamide III.
Original language | English |
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Pages (from-to) | 1779-1781 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 9 |
Early online date | 30 Mar 2006 |
DOIs | |
Publication status | Published - 2006 |
Keywords
- halo enamide prepn
- copper catalyst coupling lactam chlorovinyl bromovinyl iodide