Concise synthesis of taxol A-ring components

Remote diastereoselective additions of alkenyl lithiums to aldehydes

C. Frost, P. Linnane, P. Magnus, M. Spyvee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to aldehydes; 7 is also readily elaborated into the acetal 10.
Original languageEnglish
Pages (from-to)9139-9142
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number51
DOIs
Publication statusPublished - 16 Dec 1996

Fingerprint

Bromine
Acetals
Paclitaxel
Lithium
Aldehydes
Chlorides
Acids

Cite this

Concise synthesis of taxol A-ring components : Remote diastereoselective additions of alkenyl lithiums to aldehydes. / Frost, C.; Linnane, P.; Magnus, P.; Spyvee, M.

In: Tetrahedron Letters, Vol. 37, No. 51, 16.12.1996, p. 9139-9142.

Research output: Contribution to journalArticle

@article{f0c92245606141f38d9241d3f6e701a2,
title = "Concise synthesis of taxol A-ring components: Remote diastereoselective additions of alkenyl lithiums to aldehydes",
abstract = "The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to aldehydes; 7 is also readily elaborated into the acetal 10.",
author = "C. Frost and P. Linnane and P. Magnus and M. Spyvee",
year = "1996",
month = "12",
day = "16",
doi = "10.1016/S0040-4039(96)02159-4",
language = "English",
volume = "37",
pages = "9139--9142",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "51",

}

TY - JOUR

T1 - Concise synthesis of taxol A-ring components

T2 - Remote diastereoselective additions of alkenyl lithiums to aldehydes

AU - Frost, C.

AU - Linnane, P.

AU - Magnus, P.

AU - Spyvee, M.

PY - 1996/12/16

Y1 - 1996/12/16

N2 - The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to aldehydes; 7 is also readily elaborated into the acetal 10.

AB - The acid chloride 6 provides access to 7 (R,S and S,S) which upon bromine-lithium exchange undergoes remarkably highly diastereoselective additions to aldehydes; 7 is also readily elaborated into the acetal 10.

UR - http://www.scopus.com/inward/record.url?scp=0030590991&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1016/S0040-4039(96)02159-4

U2 - 10.1016/S0040-4039(96)02159-4

DO - 10.1016/S0040-4039(96)02159-4

M3 - Article

VL - 37

SP - 9139

EP - 9142

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 51

ER -