Computational Studies of a Novel Magnetically Driven Single-Use-Technology Bioreactor: A Comparison of Mass Transfer Models

Research output: Contribution to journalArticle

Abstract

This work applies computational fluid dynamics (CFD) modelling to a novel 1,000 litre design of single-use-technology (SUT) bioreactor, with a magnetically driven floor-mounted impeller and spargers distributed across the tank floor. A two-phase Euler-Euler model using the k-ε turbulence model and population balance is presented alongside the use of immersed solid method for modelling the impeller motion. This work also provides the first CFD analysis of a large-scale SUT bioreactor, identifying key flow characteristics of the non-standard design at different operating conditions. Five models for the mass transfer coefficient, k_L, are compared, with k_L a values compared to experimental measurements. The slip velocity model is found to be the best prediction of the mass transfer coefficient for this SUT system. Separating the influence of the mass transfer coefficient and specific area, a, shows that the latter is the dominant driving force behind changes in k_L a that occur at different operating conditions. Comparing the present work to previous studies for traditional stirred tanks highlights the need for understanding the hydrodynamics of non-standard reactor designs when identifying suitable mass transfer models in gas-liquid flow systems.
Original languageEnglish
Pages (from-to)157-173
JournalChemical Engineering Science
Volume187
DOIs
Publication statusPublished - 21 Sep 2018

Fingerprint

Bioreactors
Mass transfer
Computational fluid dynamics
Turbulence models
Dynamic analysis
Hydrodynamics
Gases
Liquids

Cite this

@article{67b329f112b44a7a86f1a4f6046ef0e0,
title = "Computational Studies of a Novel Magnetically Driven Single-Use-Technology Bioreactor: A Comparison of Mass Transfer Models",
abstract = "This work applies computational fluid dynamics (CFD) modelling to a novel 1,000 litre design of single-use-technology (SUT) bioreactor, with a magnetically driven floor-mounted impeller and spargers distributed across the tank floor. A two-phase Euler-Euler model using the k-ε turbulence model and population balance is presented alongside the use of immersed solid method for modelling the impeller motion. This work also provides the first CFD analysis of a large-scale SUT bioreactor, identifying key flow characteristics of the non-standard design at different operating conditions. Five models for the mass transfer coefficient, k_L, are compared, with k_L a values compared to experimental measurements. The slip velocity model is found to be the best prediction of the mass transfer coefficient for this SUT system. Separating the influence of the mass transfer coefficient and specific area, a, shows that the latter is the dominant driving force behind changes in k_L a that occur at different operating conditions. Comparing the present work to previous studies for traditional stirred tanks highlights the need for understanding the hydrodynamics of non-standard reactor designs when identifying suitable mass transfer models in gas-liquid flow systems.",
author = "Richard Maltby and Shuai Tian and Yong-Min Chew",
year = "2018",
month = "9",
day = "21",
doi = "10.1016/j.ces.2018.05.006",
language = "English",
volume = "187",
pages = "157--173",
journal = "Chemical Engineering Science",
issn = "0009-2509",
publisher = "Elsevier",

}

TY - JOUR

T1 - Computational Studies of a Novel Magnetically Driven Single-Use-Technology Bioreactor: A Comparison of Mass Transfer Models

AU - Maltby, Richard

AU - Tian, Shuai

AU - Chew, Yong-Min

PY - 2018/9/21

Y1 - 2018/9/21

N2 - This work applies computational fluid dynamics (CFD) modelling to a novel 1,000 litre design of single-use-technology (SUT) bioreactor, with a magnetically driven floor-mounted impeller and spargers distributed across the tank floor. A two-phase Euler-Euler model using the k-ε turbulence model and population balance is presented alongside the use of immersed solid method for modelling the impeller motion. This work also provides the first CFD analysis of a large-scale SUT bioreactor, identifying key flow characteristics of the non-standard design at different operating conditions. Five models for the mass transfer coefficient, k_L, are compared, with k_L a values compared to experimental measurements. The slip velocity model is found to be the best prediction of the mass transfer coefficient for this SUT system. Separating the influence of the mass transfer coefficient and specific area, a, shows that the latter is the dominant driving force behind changes in k_L a that occur at different operating conditions. Comparing the present work to previous studies for traditional stirred tanks highlights the need for understanding the hydrodynamics of non-standard reactor designs when identifying suitable mass transfer models in gas-liquid flow systems.

AB - This work applies computational fluid dynamics (CFD) modelling to a novel 1,000 litre design of single-use-technology (SUT) bioreactor, with a magnetically driven floor-mounted impeller and spargers distributed across the tank floor. A two-phase Euler-Euler model using the k-ε turbulence model and population balance is presented alongside the use of immersed solid method for modelling the impeller motion. This work also provides the first CFD analysis of a large-scale SUT bioreactor, identifying key flow characteristics of the non-standard design at different operating conditions. Five models for the mass transfer coefficient, k_L, are compared, with k_L a values compared to experimental measurements. The slip velocity model is found to be the best prediction of the mass transfer coefficient for this SUT system. Separating the influence of the mass transfer coefficient and specific area, a, shows that the latter is the dominant driving force behind changes in k_L a that occur at different operating conditions. Comparing the present work to previous studies for traditional stirred tanks highlights the need for understanding the hydrodynamics of non-standard reactor designs when identifying suitable mass transfer models in gas-liquid flow systems.

U2 - 10.1016/j.ces.2018.05.006

DO - 10.1016/j.ces.2018.05.006

M3 - Article

VL - 187

SP - 157

EP - 173

JO - Chemical Engineering Science

JF - Chemical Engineering Science

SN - 0009-2509

ER -